Senior Clinical Scientist
About The Position
Jade Biosciences is a clinical-stage biotechnology company developing therapies for unmet needs in autoimmune diseases. Its lead candidate, JADE101, targets APRIL and is being evaluated for immunoglobulin A nephropathy. The company’s pipeline also includes JADE201, an afucosylated anti-BAFF-R monoclonal antibody, and JADE301, an anti-IFN-β monoclonal antibody. Jade Biosciences is seeking a highly motivated and experienced Senior Clinical Scientist to support clinical development programs in nephrology, particularly rare or immune-mediated kidney diseases. The role translates clinical strategy into high-quality execution of late-stage clinical trials and serves as the Clinical Scientist for one or more Phase 2 and/or Phase 3 studies. This newly created position reports to the Executive Medical Director of Clinical Development. It is fully remote and requires periodic travel for investigator meetings, study team meetings, conferences, and other business activities. The Senior Clinical Scientist contributes to study design, protocol development, study documentation, scientific oversight, data review and interpretation, regulatory support, and cross-functional study execution. The role also supports scientific communications and external scientific interactions, while maintaining alignment with ICH-GCP, applicable regulations, and company standards.
Requirements
- Advanced degree in life sciences, nursing, pharmacy, public health, or a related discipline (PharmD, PhD, MS, MPH, or equivalent).
- Minimum 5–8 years of clinical research experience in the biotechnology, pharmaceutical, or CRO industry.
- Experience supporting Phase 2 and/or Phase 3 clinical trials.
- Strong understanding of clinical trial design, clinical data review, and drug development.
- Working knowledge of ICH-GCP, FDA, EMA, and global regulatory requirements.
- Experience reviewing clinical data and collaborating with biostatistics and data management teams.
- Excellent project management, communication, and organizational skills.
- Ability to work independently and manage multiple priorities in a fast-paced environment.
- Strong scientific and analytical thinking.
- Attention to detail and focus on data quality.
- Excellent written and verbal communication skills.
- Collaborative, team-oriented mindset and ability to influence across functions without direct authority.
- Comfort operating in a highly dynamic, entrepreneurial environment.
- Proactive, hands-on, and solution-oriented approach.
Nice To Haves
- Experience in nephrology, immunology, inflammation, autoimmune diseases, or rare diseases.
- Experience with global multicenter clinical trials.
- Prior involvement in regulatory submissions and health authority interactions.
- Experience contributing to scientific publications and conference presentations.
- Experience working in a small or emerging biotechnology company.
Responsibilities
- Serve as the Clinical Scientist for one or more Phase 2 and/or Phase 3 clinical studies.
- Contribute to study design, protocol development, and protocol amendments.
- Develop and review protocols, Investigator’s Brochures, Informed Consent Forms, clinical study reports, study manuals, training materials, and safety management plans.
- Provide scientific oversight during study conduct to support protocol compliance and data quality.
- Partner with Clinical Operations on study start-up, enrollment, trial execution, and close-out.
- Participate in investigator meetings, site training, and scientific discussions with investigators and key opinion leaders.
- Lead ongoing data review and medical monitoring activities in collaboration with Medical Monitors.
- Identify clinical trends, protocol deviations, safety signals, and data quality issues.
- Collaborate with Data Management and Biostatistics on data review plans, edit check specifications, and endpoint derivation and analysis plans.
- Participate in database lock, data cleaning, and analysis activities.
- Contribute to interpretation of study results and development of key messages.
- Support regulatory submissions and agency interactions, including briefing documents and responses to regulatory questions.
- Ensure study conduct aligns with ICH-GCP, applicable regulations, and company standards.
- Collaborate across Clinical Development, Clinical Operations, Biometrics, Regulatory, Safety, Medical Affairs, and Medical Writing.
- Drive timelines, track deliverables, and proactively identify and mitigate risks.
- Support governance meetings and prepare study review materials.
- Contribute to abstracts, presentations, manuscripts, and scientific publications.
- Participate in advisory boards, investigator meetings, and key external scientific interactions.
- Maintain awareness of evolving scientific, clinical, and competitive landscapes.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
