Senior Associate Scientist, Translational Research, Oncology
About The Position
The Protein Homeostasis Research Center (TRC) at BMS is a key engine for discovering and developing oncology therapeutics. The TRC focuses on leveraging BMS' expertise in protein degradation to create therapies targeting tumor-intrinsic vulnerabilities and resistance mechanisms to existing cancer treatments. This approach allows for the targeting of previously undruggable protein classes. The group spans discovery research through translational and early clinical development, utilizing advanced in vitro, in vivo, and ex vivo models of cancer biology to identify and validate targets. They collaborate closely with colleagues in Translational Development, Informatics and Predictive Sciences, and Early Clinical Development to generate biomarker and patient enrichment hypotheses, facilitating informed decision-making in early clinical trials. This specific role is a bench-facing research position focused on in-vitro techniques to support translational biomarker work, indications, and assay development, with a keen interest in the biology and therapeutic potential of regulated protein turnover and stability being beneficial.
Requirements
- Bachelor’s Degree with 4+ years of academic and / or industry experience OR Master’s Degree with 2+ years of academic and / or industry experience.
- Highly motivated, collaborative, and creative.
- Ability to work across a highly matrixed environment to develop and implement experiments supporting translational development of novel therapeutics in oncology.
- Self-starter and team player who can effectively collaborate with colleagues in the protein homeostasis, oncology, protein engineering/antibody development, chemistry, biomarker, and clinical groups.
- Proven track record in a relevant scientific area and strong technical skills.
- Clear and professional verbal and written communication skills, capable of presenting scientific results to multidisciplinary teams and key stakeholders.
- Experience evaluating and applying technologies in genome, transcriptome, and proteome characterization to preclinical and clinical samples.
Nice To Haves
- B.S. in a scientific discipline with at least 5 years of work experience or M.S. with at least 3 years of experience, preferably in industry and cancer biology.
- Hands on experience with various in-vitro cellular and biochemical assays, including: 2D/3D cell culture (BSL2+), in-vitro assays (e.g., co-cultures, transfections, shRNA, CRISPR technology, CTG, IncuCyte, and other cell-based assays), in-vivo sample processing (xenografts and other specimens), RNA analyses (e.g., qPCR, Nanostring), protein analyses (e.g., Westerns, MSD, ELISAs, Flow Cytometry, IP, HCS, IHC, fluorescent microscopy).
- Familiarity with next-generation sequencing technologies, including RNA-seq, whole exome/genome sequencing, ChIP-seq.
- Aptitude in experimental design, execution, data analysis and troubleshooting.
- In touch with new technology, assays, automation, and innovative in approaches to complex problems.
- Data mining proficiency with public and internal databases (e.g., UCSC genome browser, DepMap, cBIO).
- Proficiency in utilizing software such as Graph Pad, E-notebook, Microsoft office, FlowJo, etc. for data analyses and figure generation.
- Attention to detail with excellent organizational and record keeping skills.
- Excellent interpersonal skills with the ability to interact effectively with diverse types of people, internally and externally.
- Familiarity with the drug development process, translational work, and knowledge of assay design, creation, and validation.
- Ability to stay focused, with attention to details, and to deliver high quality data in a timely and well-organized manner.
- Ability to handle multiple projects and work in a fast-paced dynamic team environment.
- Initiative, responsibility, and flexibility to adapt to changes with a positive attitude.
Responsibilities
- Conduct full time laboratory-based research supporting translational research experiments in the context of preclinical and early-phase clinical trials.
- Participate on cross-site, cross-functional, and geographically diverse teams.
- Work with translational scientists whose activities span cell-based, in vivo, and clinical trial assays, samples, and data.
- Work on selection, validation, and deployment of novel clinical-stage assays and analyses of data to accelerate development and provide insight into disease biology and drug mechanisms.
- Execute experiments to test hypotheses from clinical observations in preclinical model systems.
- Review scientific papers/protocols and apply appropriately to project needs.
- Help execute collaborative projects with leading academic and commercial research groups worldwide.
Benefits
- Medical, pharmacy, dental, and vision care.
- BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
- 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
- Flexible time off (unlimited, with manager approval, 11 paid national holidays) for US Exempt Employees.
- 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays for Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees.
- Unlimited paid sick time (based on eligibility).
- Up to 2 paid volunteer days per year.
- Summer hours flexibility.
- Leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs.
- Annual Global Shutdown between Christmas and New Years Day.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
