Senior Associate Scientist, LNP Formulations

Alnylam Pharmaceuticals•Cambridge, MA

3d•$80,000 - $120,000•Onsite

About The Position

We are looking for a highly motivated, enthusiastic, and innovative candidate for the role of Senior Associate Scientist of Lipid Nanoparticle (LNP) formulations within Formulation Sciences team. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. The successful candidate will have scientific background in LNP formulations, as well as drug delivery systems and analytical techniques. They should be an independent problem-solver, collaborative, and comfortable working in a fast-paced entrepreneurial environment. This position is onsite and will be primarily located at 675 W Kendall St, Cambridge, MA 02142.

Requirements

BS/MS in Chemical Engineering, Material Science and Engineering, Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 2-4 years of industry experience with a focus on LNP formulation and delivery systems
Direct experience in LNP formulation (in-line mixing and TFF), characterization (DLS, NTA, zeta potential, UV/fluorescence spectroscopy, HPLC, UPLC, ribogreen assay, capillary electrophoresis, gel electrophoresis, etc.), mRNA and siRNA encapsulation, and QC analysis is a must
Ability to work on multiple projects simultaneously and deliver conclusive results
Ability to quickly adapt to new priorities with responsibility in a fast-paced, dynamic, innovative environment
Goal oriented, highly organized with significant attention to details while maintaining highest scientific and ethical standards
Strategic and forward thinking
Strong team player with excellent verbal and written communication skills

Nice To Haves

Experience in high-throughput formulation screening will be plus
Experience in antibody or small molecule formulations/analysis and drug delivery systems will be plus

Responsibilities

Conduct LNP formulation optimization and characterization
Support in vitro/in vivo studies by producing LNPs encapsulating siRNAs and/or mRNAs
Generate analytical data to understand physicochemical parameters of LNPs across various payloads and to support projects in research/development
Support novel method development of LNP characterization and LNP delivery
Support formulations and analysis within formulation sciences team
Design, plan and perform scientific experiments and contribute to project related scientific activities with some guidance from team members
Analyze, summarize experimental data, and present scientific findings in the cross-functional teams
Maintain electronic lab notebook, SOPs, appropriate documentation for scientific data and experimental protocols
Work closely with scientists in Medicinal Chemistry, RNAi biology, and early development teams