Senior Associate Scientist - In Vivo Pharmacology

Merck•Billerica, MA

2d•Onsite

About The Position

EMD Serono in Billerica, MA, is seeking a Senior Associate Scientist – In Vivo Pharmacology. The In Vivo Pharmacology Senior Associate Scientist will be responsible for the hands-on execution of in vivo pharmacology studies that utilize mouse tumor models to study the anti-tumor activity of novel oncology and immuno-oncology agents. The Senior Associate Scientist will work under supervision and collaboratively as part of an in vivo pharmacology team and will be responsible for study execution, data analysis and generation of electronic notebooks. The successful candidate will support multiple projects and provide high-quality data packages within project timelines.

Requirements

Master’s degree in Biology, Pharmacology, Oncology, Immunology, or other Life Science discipline with 1+ years of hands-on experience with administering compounds via various routes (PO, IV, IP, SC) and blood/tissue collection OR Bachelor’s degree in Biology, Pharmacology, Oncology, Immunology, or other Life Science discipline with 3+ years of hands-on experience with administering compounds via various routes (PO, IV, IP, SC) and blood/tissue collection
External applicants must be eligible to work in the US.

Nice To Haves

Proficiency in handling rodents and hands-on in vivo pharmacology skills, including dosing (PO, IV, IP, SC), preparation of test compounds, anesthesia, necropsy, blood and tissue collection
Experience with standard laboratory techniques including cell culture, aseptic techniques and sterile handling of biological samples
Familiarity with data analysis software such as Graph Pad Prism and Microsoft Office
Previous experience with animal models of cancer, including syngeneic models, xenograft models and humanized models, and understanding of their applications and limitations
Proficiency in tumor cell implantation, tumor measurements, and in vivo small animal imaging
Understanding and familiarity with immunological readouts, E.g. FACS-based immunophenotyping, cytokine profiling (multiplex assays), assessment of tumor immune infiltrates, and functional assays (ELISPOT, cytotoxicity assays)
Demonstrated ability to work in a diverse team setting and collaborate effectively on multiple projects.
Excellent oral and written communication skills
Team player with excellent interpersonal skills and ability to collaborate with cross-functional teams
Well-organized and self-directed; able to adhere to tight timelines
Forward-thinking and creative with high ethical standards
Detailed oriented and eager to learn

Responsibilities

Conduct in vivo studies, including mouse handling, compound formulation and dosing via multiple routes of administration.
Perform necropsy, tissue and blood collection.
Prepare and process tissue for downstream analysis.
Maintenance of mammalian cell culture or primary immune cells using aseptic techniques.
Collect and document data using electronic notebooks to maintain detailed records of study design, experimental procedures and data analysis.
Follow IACUC protocols and standard operating procedures (SOPs) in accordance with company policy.