Senior Advisor, Clinical Science (remote)

Lilly • Indianapolis, IN

6d • $153,000 - $268,400 • Remote

About The Position

Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is seeking a Senior Advisor, Clinical Science to serve as a scientific partner to the study team and medical monitor in executing and interpreting primarily Phase 2–3 clinical trials for Orexin-targeted sleep/wake programs. The role performs at the Associate Director level and provides clinical and scientific expertise to day-to-day study conduct, ensuring trials follow the protocol, internal processes, GCP/ICH and regulatory requirements, and the broader clinical development strategy.

The position contributes across protocol development, study startup, trial execution, recruitment, monitoring, and data analysis at closeout. It is a key cross-functional partner to Clinical Operations, Translational Science, Regulatory Affairs, Biostatistics, and Safety/Pharmacovigilance. The role is remote in the US with occasional travel and reports to the Executive Director, Clinical Development.

Requirements

• PhD or PharmD in an advanced scientific/clinical discipline and at least 2 years of drug development experience in the biotech/pharma industry; or a BS/MS in a scientific discipline and at least 8 years of drug development experience in the biotech/pharma industry.
• Strong scientific foundation in neuroscience/neurology.
• Understanding of clinical trial design, clinical data analysis, and drug development principles.
• Demonstrated accountability for delivery on clinical studies.
• Proven experience developing and authoring clinical and regulatory documents, such as protocols, Investigator Brochures, Clinical Study Reports, and briefing documents.

Nice To Haves

• Familiarity with Orexin biology or related sleep/wake and neurocircuitry mechanisms.
• Detail orientation and exceptional organizational skills.
• Effective verbal and written communication skills.
• Ability to identify issues, analyze situations, and provide effective solutions.
• Demonstrated ability to partner with cross-functional teams in a fast-paced biotech environment.

Responsibilities

• Serve as clinical scientist on one or more late-stage (Phase 2–3) global clinical trials for Orexin-targeted programs in sleep/wake indications.
• Support the creation of and/or review clinical slides for internal and external meetings, including Investigator Meetings, SIVs, IDMCs, and Advisory Boards.
• Assist in authoring clinical study documents, including protocols, Clinical Study Reports, Investigator Brochures, and Development Safety Update Reports.
• Serve as the study scientific expert from startup through Clinical Study Report completion, including CRF design, enrollment monitoring, and patient profile review.
• Act as the primary liaison for internal Clinical Operations on site selection, site startup, study management, and closeout activities.
• Serve as a primary contact for clinical inquiries from sites, CROs, site monitors, and health authorities; answer or triage questions as appropriate and integrate clinical/regulatory strategy into global product development strategy.
• Conduct ongoing clinical data review to monitor safety, data integrity, protocol compliance, and study performance.
• Serve as a core scientific leader on cross-functional program and study teams, partnering with Clinical Operations, Regulatory Affairs, Biostatistics, and Safety/Pharmacovigilance.
• Drive cross-functional alignment and execution to support high-quality, timely study delivery.
• Proactively identify and address scientific, operational, and strategic risks and gaps.
• Develop scientific insights and recommendations to inform clinical development strategy and decision-making.
• Partner with Biostatistics on development and review of the SAP and review and interpret final clinical study TLFs.
• Support preparation of abstracts, posters, manuscripts, and presentations for scientific meetings and publications.
• Provide scientific leadership in interactions with investigators, CROs, vendors, and external experts.
• Represent Clinical Science in interactions with key opinion leaders and scientific advisory boards in sleep/wake disorders.
• Manage deliverables across assigned studies and workstreams with strong organization, follow-through, and proactive oversight.

Benefits

• Eligibility to participate in a company-sponsored 401(k).
• Pension.
• Vacation benefits.
• Eligibility for medical, dental, vision, and prescription drug benefits.
• Flexible benefits, including healthcare and/or dependent day care flexible spending accounts.
• Life insurance and death benefits.
• Certain time off and leave of absence benefits.
• Well-being benefits, including an employee assistance program, fitness benefits, and employee clubs and activities.
• Company bonus eligibility, depending in part on company and individual performance.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior