Scientist

Roche•Pleasanton, CA

1d•$111,000 - $206,500•Onsite

About The Position

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. The Position We are looking for a highly motivated and skilled Principal Scientist to support the development of advanced molecular diagnostics technologies. This role requires expertise in both preparative chromatography and analytical techniques, spanning the entire product development lifecycle—from early-stage research through on-market support. As part of the Chemistry Team, you will have access to cutting-edge technologies and state-of-the-art instrumentation, enabling you to contribute meaningfully to advancements in molecular diagnostics. Your work will directly impact global health, pushing the boundaries of what's possible in the field of diagnostics.

Requirements

Ph.D. in Chemistry, Biochemistry, Chemical Biology, Medical Chemistry (or a related field) and have at least 2+ years of relevant industry experience, OR a Master’s Degree in Chemistry, Biochemistry, Chemical Biology, Medical Chemistry (or a related field) with 5+ years of industry experience
Demonstrated experience and problem-solving skills in UPLC/HPLC, ion pair chromatography, ion exchange, advanced mass spectrometry, absorption spectroscopy, and fluorescence spectroscopy.
High level of knowledge of synthetic methods for nucleotides, phosphoramidites, oligonucleotides (including post-synthetic modification) and considerable understanding of PCR methodologies.
Demonstrated in-depth knowledge of DNA, RNA, modified oligonucleotides (including dye- and non-natural modifications), and small molecule reagents.
Strong level of expertise in purifying and characterizing oligonucleotides and small molecules.
Proven skills in experimental design, particularly in developing and optimizing sophisticated analytical assays applied to oligonucleotides and PCR.

Nice To Haves

Attention to detail and technical writing skills enable you to prepare clear, detailed documentation, including analytical reports.
Proactive approach to problem-solving, a growth mindset, and a passion for contributing to a collaborative workplace culture.
Demonstrated Interpersonal skills: Strong verbal communication and influencing skills; can influence without authority and has proven experience building and cultivating relationships with key partners and stakeholders, both internally and externally

Responsibilities

Synthesize, purify, characterize complex nucleotides, phosphoramidites, oligonucleotides, their analogs, and related small molecule reagents.
Drive process optimization to enable efficient scale-up and successful product launches.
Support and utilize analytical methods for characterizing reagents, reactions, and assay performance, with applications spanning R&D and Operations.
Design and execute advanced troubleshooting experiments independently and in collaboration with cross-functional teams.
Develop assays that push the limits of system understanding and error detection to ensure robust designs.
Manage knowledge handoffs of prototype methods and assist in transferring comprehensive documentation from research stages to development and manufacturing teams.
Act as a subject matter expert to provide technical depth across R&D departments and operations.