Scientist

Intellia Therapeutics, Inc.•Cambridge, MA

7d•$123,300 - $150,700•Onsite

About The Position

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together. We are seeking a Scientist to join our Translational Medicine group, focused on discovery proteomics to identify and characterize biomarkers and profile immune recognition of therapeutic candidates. The ideal candidate will bring hands-on mass spectrometry expertise across biomarker discovery workflows and immunopeptidomics, with experience in top-down or native protein mass spectrometry considered a strong plus. This is a hands-on, laboratory-based role where your data will directly inform how we evaluate and advance our therapeutic candidates.

Requirements

Hands-on experience with immunopeptidomics workflows, including MHC/HLA immunoprecipitation and low-abundance peptide LC-MS/MS
Experience with native and/or intact protein mass spectrometry
Familiarity with HLA-binding prediction tools and immunopeptidomics-specific proteomics search software
Strong bioanalytical and structural mass spectrometry background
Strong problem-solving skills, with the ability to apply in-depth theoretical knowledge to complex technical challenges within a defined scientific area
Ability to execute studies, manage outlined timelines, and ensure data quality
Ability to draw conclusions from experimental results and apply them to new experiments
Excellent organizational, written, and verbal communication skills
Strong interpersonal skills and the ability to prioritize effectively across competing demands
Comfortable operating in a fast-paced, deadline-driven environment
PhD in a biological or relevant technical/engineering field, or equivalent through a combination of education and experience
0–3+ years of relevant experience post-PhD (or 6–9+ years with an MS, or 8–11+ years with a BS)
Must be able to lift up to 15 pounds at times.
Prolonged periods of sitting at a desk and working on a computer.

Nice To Haves

Experience in top-down or native protein mass spectrometry

Responsibilities

Design and execute discovery proteomics workflows — including sample preparation, LC-MS/MS data acquisition, and downstream bioinformatic analysis — to identify and characterize candidate biomarkers across biological matrices.
Develop and run immunopeptidomics workflows, from MHC class I/II immunoaffinity purification through peptide elution, cleanup, and nanoflow LC-MS/MS, to profile HLA-presented peptides and characterize immune recognition of therapeutic candidates.
Analyze complex proteomics and immunopeptidomics datasets using specialized search software and bioinformatic tools, translating results into clear, actionable insights.
Apply top-down and/or native mass spectrometry approaches, where relevant, to characterize protein higher-order structure, complex integrity, and post-translational modifications (a valued but not required skill set).
Select and optimize separation chemistry and MS platforms best suited to each analyte and biological question.
Plan and lead well-defined assay development and discovery projects end-to-end, independently identifying the broader objectives each project should address.
Author assay methods, SOPs, and bioanalytical/risk assessment reports, and partner closely with immunology, process development, and other cross-functional teams to communicate findings.