Scientist, Genome Sciences & Engineering

Stylus Medicine • Cambridge, MA

1d

About The Position

Stylus Medicine is developing in vivo genetic medicines by combining engineered recombinases with non-viral delivery. The Scientist will join the Genome Sciences & Engineering team and drive in vitro functional assessment of lead genome editors to support the advancement of programs through translational and preclinical development. The role contributes to discovery and engineering efforts, advances LSR-based genome-editing platforms, and collaborates across R&D teams.

Requirements

• PhD in Cell Biology, Molecular Biology, or a related field; alternatively, an MS with 5+ years or a BS with 7+ years of relevant experience.
• Hands-on experience with LNP delivery.
• Expertise culturing primary cells, including but not limited to T-cells and hepatocytes, and/or cancer cell lines.
• Working knowledge of gene-editing technologies such as CRISPR nucleases, recombinases, base editors, or transcriptional effectors.
• Experience with flow cytometry and laboratory automation platforms for cell-based screening workflows.
• Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR.
• Track record of independently generating reproducible data and performing rigorous quantitative analysis.
• Strong written and verbal communication skills, including the ability to present complex technical information to specialist and non-specialist audiences.
• Exceptional organizational skills and comfort managing complex datasets and overlapping projects.
• Strategic thinking and ability to plan and prioritize for scientific impact.
• Clear, approachable communication skills and ability to make complex concepts accessible across disciplines.
• Collaborative mindset and team-first attitude.
• Decisive problem-solving skills and ability to thrive amid scientific uncertainty.

Responsibilities

• Design and execute in vitro functional assays to support candidate selection and preclinical development of lead genome editors and advance platform and program objectives.
• Develop and optimize molecular assays, including ddPCR and qPCR, and cytogenetic assays, including KromaTiD and optical genome mapping, to measure genome-editor activity, specificity, transgene copy number, TCR repertoire, and biodistribution.
• Support genome-editor engineering campaigns by running high-throughput screens in relevant cell lines, including primary human T-cells, and delivering timely, decision-quality data to guide candidate selection.
• Troubleshoot experiments, analyze data, and translate results into actionable scientific insights.
• Maintain detailed laboratory notebooks and clearly communicate data and findings to the broader scientific team.
• Partner across R&D to advance optimized candidates into translational and preclinical development.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree