Scientist

Guidehouse•Bethesda, MD

2d•Onsite

About The Position

We are currently searching for a Scientist to provide support to the planning and execution of research experiments. This is a full-time, on-site opportunity in Bethesda, MD. Contribute to the development and optimization of lipid nanoparticle formulations and mRNA constructs for applications in cancer and infectious diseases. Generate, analyze, and interpret experimental data to support translational decision making and technology advancement. Evaluate and help implement enabling technologies that improve vaccine potency, safety, stability, and manufacturability. Collaborate closely with multidisciplinary teams, including discovery scientists, formulation scientists, and manufacturing and regulatory partners. Oversee project data quality; analyze and interpret project data. Design and execute in vitro and in vivo studies to evaluate biodegradability, biodistribution, safety, immunogenicity, and efficacy. Maintain accurate experimental records and prepare technical reports, presentations, and summaries for internal stakeholders. Ensure studies are conducted in compliance with institutional, regulatory, and animal care guidelines. Contribute to the scientific mission of the Vaccine Research Center (VRC) through innovation and collaboration.

Requirements

Master’s degree
A minimum of THREE (3) years of experience in immunology, vaccine development, or related scientific research.
Demonstrated expertise in mRNA and/or lipid nanoparticle (LNP) technologies, vaccine platforms, or nucleic acid delivery systems.
Hands on experience with in vivo animal models relevant to vaccines, immunology, oncology, or infectious diseases.
Strong background in translational research, with the ability to connect discovery findings to development objectives.
Experience with experimental design, data analysis, and scientific documentation.
Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse.

Nice To Haves

Ph.D. in immunology, molecular biology, bioengineering, or a related field (or equivalent combination of education and experience).
Experience working within federal research environments such as NIH or similar agencies.
Prior experience supporting translational or clinical-stage research programs.
Familiarity with regulatory and manufacturing considerations in biologics development.
Candidates with an active public trust or suitability are preferred.

Responsibilities

Contribute to the development and optimization of lipid nanoparticle formulations and mRNA constructs for applications in cancer and infectious diseases.
Generate, analyze, and interpret experimental data to support translational decision making and technology advancement.
Evaluate and help implement enabling technologies that improve vaccine potency, safety, stability, and manufacturability.
Collaborate closely with multidisciplinary teams, including discovery scientists, formulation scientists, and manufacturing and regulatory partners.
Oversee project data quality; analyze and interpret project data.
Design and execute in vitro and in vivo studies to evaluate biodegradability, biodistribution, safety, immunogenicity, and efficacy.
Maintain accurate experimental records and prepare technical reports, presentations, and summaries for internal stakeholders.
Ensure studies are conducted in compliance with institutional, regulatory, and animal care guidelines.
Contribute to the scientific mission of the Vaccine Research Center (VRC) through innovation and collaboration.

Benefits

Medical, Rx, Dental & Vision Insurance
Personal and Family Sick Time & Company Paid Holidays
Parental Leave
401(k) Retirement Plan
Group Term Life and Travel Assistance
Voluntary Life and AD&D Insurance
Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
Transit and Parking Commuter Benefits
Short-Term & Long-Term Disability
Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
Employee Referral Program
Corporate Sponsored Events & Community Outreach Care.com annual membership
Employee Assistance Program
Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
Position may be eligible for a discretionary variable incentive bonus