FSP - Scientist - Transient Expression

Thermo Fisher Scientific • San Diego, CA

9d • Onsite

About The Position

This is a fully onsite role based at our customer’s site in San Diego, CA. Thermo Fisher Scientific's clinical research business is a leading global contract research organization and world leader in serving science. We are passionate, deliberate, and driven by our mission – to enable our customers to make the world healthier, safer, and cleaner. Our Laboratories Functional Service Partnership (FSP) team plays a direct role in advancing drug development by creating sustained groups of talent within our customers’ organizations to provide long-term support. Through this collaborative approach, our professionals bring their commitment to excellence, industry knowledge, and operational strength directly into customer environments, helping to enhance capabilities and advance the delivery of life-changing therapies.

Requirements

• Bachelor's degree in lab sciences such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology or similar.
• Scientist: Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 2+ years’) OR Masters degree.
• In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.
• Experience with cell culture and transient transfection in CHO and HEK293 cells.
• Experience with antibody expression/production.
• Knowledge of stable cell line development.
• Knowledge of protein expression using a bioreactor.
• Able to execute experiments efficiently and suggest small process improvements.
• Recognizes fundamental anomalies in data points and identifies issues in experiments / processes.
• Begins to understand how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals.
• Strong knowledge of scientific discipline.
• Good knowledge of scientific principles, methods and techniques.
• Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools.
• Strong computer skills.
• Good problem-solving, analytical thinking skills.
• Detail oriented.
• Ability to meet deadlines.
• Excellent communication skills with the ability to collaborate with cross-functional scientists.
• Ability to maintain accurate detailed documentation of experiments essential.
• Willingness and ability to work both independently and as part of a team.
• Must be legally authorized to work in the United States without sponsorship.
• Must be able to pass a comprehensive background check, which includes a drug screening.

Nice To Haves

• Some experience with AAV expression is also desirable but not required.
• Experience with AAV expression would be highly desirable.
• Knowledge of standard molecular biology cloning techniques is a plus.

Responsibilities

• Production of monoclonal antibodies and other proteins via molecular cloning, DNA preparation, cell line maintenance, transient transfection of production cell lines, and stable cell line production.
• Design and perform studies.
• Work collaboratively with colleagues across the R&D organization to support the development of biological therapeutics.
• Assist with cell culture, transient transfection, expression optimization, DNA preparation, and protein quantification.
• Culture mammalian cell lines for DNA transfection with rigorous sterile technique.
• Explore potential improvements to the existing protein expression platform under the direction of a senior scientist.
• Optimize experimental procedures drawing on available literature and previous results.
• Partner in the development of a stable cell line expression platform for research purposes.
• Work with bioreactors for transient and stable CHO expression.
• Prepare detailed data reports and presents results to peers and colleagues.
• Other duties as assigned.

Benefits

• Competitive remuneration
• Annual incentive plan bonus
• Healthcare
• A range of employee benefits
• A choice of national medical and dental plans, and a national vision plan, including health incentive programs
• Employee assistance and family support programs, including commuter benefits and tuition reimbursement
• At least 120 hours paid time off (PTO)
• 10 paid holidays annually
• Paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave)
• Accident and life insurance
• Short- and long-term disability in accordance with company policy
• Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
• Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level