Scientist/Sr. Scientist, Spatial Omics Technology Development (Fixed-Term Contract)
About The Position
We are looking for an outstanding scientist / senior scientist for a fixed term of 18 months to join our Multi-Omic Technology Center focusing on imaging-based spatial technology development for the Alzheimer's Disease Initiative. You will work closely with the spatial technology lead and collaborators across Arc tech centers and innovation investigators, to stabilize a custom imaging platform, adapt homebrew chemistry to arrayed human organoids, and help move our in-house spatial perturb-seq technology from proof-of-concept to a screen-ready platform for large scale studies. The ideal candidate has a passion for developing technologies and robust systems and has a track record in spatial publications or product development. The role will split between system characterization/improvement and spatial multiomic (mRNA + protein + sgRNA) chemistry/workflow optimization/ execution. This is an excellent opportunity for a highly motivated scientist interested in the intersection of academic research and biotech system/product development. This 18-month fixed-term position is based onsite 5 days a week in Palo Alto. This role is not eligible for visa sponsorship.
Requirements
- PhD in molecular biology, biochemistry, genomics, bioengineering, or a related field, with 2-5+ years of experience in academia or the biotechnology industry.
- Extensive experience in spatial omics technology and/or product development.
- Hands-on experience with custom imaging and/or fluidic systems, including instrument troubleshooting.
- Hands-on experience with tissue or organoid sample prep and in situ imaging-based assays (e.g., HCR, MERFISH, seqFISH, RCA, in situ sequencing).
- Comfortable working in a fast-paced, early-stage technology development environment with substantial hands-on troubleshooting.
- Strong collaboration and communication skills across multiple teams.
- Strong project management and documentation skills.
Nice To Haves
- Hands-on experience with tissue microarray or low-input histology is a plus.
- Experience with image processing or spatial data analysis is a plus.
- Background in neuroscience, stem cell biology, or immunology is a plus.
Responsibilities
- Design and execute system testing and validation plans for the current custom in-house spatial imaging platform.
- Work directly with external vendors to troubleshoot and resolve hardware and software issues.
- Collaborate with the spatial omics project lead and internal partners to optimize spatial multiomic chemistry and sample-prep workflows for human stem-cell-derived brain organoids, adapting protocols validated in mouse tissue.
- Execute end-to-end wet lab spatial perturb-seq workflows.
- Collaborate with computational scientists to analyze imaging QC data and drive iterative assay development and decision-making.
- Track progress against key milestones and report on progress in internal meetings.
- Collaborate to move projects from proof-of-concept through development and screens.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
