Scientist/Senior Scientist - Hemodynamic Biology

e184 • Portland, OR

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About The Position

e184 is a biotechnology research company working to overcome limits of human biology. Its reproductive technologies program develops ectogenesis to support human development outside the body and expand reproductive freedom. The company combines biology, engineering, and computational science to build platforms for understanding and recreating conditions for healthy human gestation beyond the uterus.

As a Scientist/Senior Scientist in Hemodynamic Biology, you will define the in vivo blood-flow properties that engineered perfusion systems must reproduce and characterize immune-system and plasma function within living tissue under those flow conditions. This bench-science-driven role establishes physiological reference points and turns findings into quantitative design targets for engineering teams. You will also contribute to in vivo reference studies and collaborate with engineers to validate engineered systems against in vivo physiology.

Requirements

• PhD in physiology, immunology, hematology, vascular biology, or a related field.
• 7+ years of relevant research experience.
• Strong understanding of in vivo blood-flow dynamics and vascular physiology.
• Strong background in immunology, particularly immune-cell function and signaling within tissue.
• Deep knowledge of plasma composition and its physiological behavior in tissue.
• Experience designing and executing in vivo or ex vivo physiological characterization studies.
• Strong data-analysis and quantitative-benchmarking skills.
• Strong collaboration and communication skills in interdisciplinary environments.
• Comfort working in a fast-paced, iterative startup environment.

Nice To Haves

• Experience with placental blood flow and uteroplacental circulation.
• Experience in reproductive immunology, particularly maternal-fetal immune interactions.
• Experience with in vivo imaging or monitoring of blood flow, such as contrast-enhanced ultrasound, Doppler, or microcirculatory imaging.
• Experience with comparative physiology across species, including rodent, nonhuman primate, and human.
• Prior experience translating in vivo physiological data into engineering specifications.

Responsibilities

• Characterize in vivo blood flow, including flow, pressure, resistance, and shear properties across relevant tissues and gestational stages, and establish physiological targets for engineered perfusion systems.
• Study resident and trafficking immune-cell populations, cytokine signaling, and immune-tolerance mechanisms in living tissue under normal blood-flow conditions.
• Characterize how plasma composition behaves and changes as it interacts with tissue in vivo, including oncotic and osmotic effects, protein binding, and delivery of tissue-relevant factors.
• Translate physiological findings into quantitative benchmarks that inform perfusate composition, flow and pressure setpoints, and monitoring requirements for engineered systems.
• Work closely with the engineering team to ensure engineered systems are validated against in vivo physiology.
• Support characterization of in vivo reference animal models and generate datasets used to benchmark engineered platforms.

Benefits

• Competitive salary; equity participation is considered.
• State-of-the-art facility in the Portland metro area.
• Comprehensive medical, dental, and vision coverage.
• 401(k) with company match.
• 20 days of PTO and 11 paid holidays.
• Work with a world-class team.
• Exposure to the full lifecycle of discovery, from screening to mechanistic validation.
• Opportunity to work at an early-stage startup described as having the stability of a well-capitalized company.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree