Sci./Sr Scientist, Molecular Pharmacology

Aktis Oncology Inc•Durham, NC

1d•$108,000 - $148,500

About The Position

The Scientist/Senior Scientist within the Molecular Pharmacology group will work in cross-functional teams to identify and develop novel therapies to treat targeted patient populations within multiple oncology indications. They will independently apply and develop cutting-edge tools and methodologies to enable advancement of company objectives with a focus on early discovery and lead optimization activities. Through project leadership and experimental activities, the team member will find solutions to program-related challenges in order to advance programs as part of the Biology Team.

Requirements

Ph.D. in a biotechnology-related field (e.g. pharmacology, biology or similar disciplines) or Bachelor’s or Master’s degree in similar disciplines with a strong track record of industry-related experience and accomplishments.
Minimum of 2 years of biopharmaceutical research experience in drug discovery and/or translational research with Ph.D. or 5+ years of experience required with Bachelor’s or Master’s degree.
Experience with application and development of basic science methodologies to support complex strategies and enable advancement of Company objectives.
Demonstrated success with the development, execution and interpretation of in vitro screening experiments to explore therapeutic potential of drug targets and drive development programs.
Strong technical background in planning, designing, executing and documenting pre-clinical in vitro pharmacology experiments in order to evaluate target biology and characterize the efficacy and safety of development candidates.
Target engagement assay development
Mammalian cell culture / cell line engineering
Knowledge of medium-throughput cell-based assays and in vitro pharmacology (e.g. ligand-binding assays)
Common molecular and biochemical techniques (DNA/RNA isolation, qPCR, Western, ELISA, antibody characterization and QC, etc.).
Demonstrated success in the areas of lead discovery and optimization.
Excellent interpersonal and collaborative skills.
Thrives in a fast-paced, ever-changing growth environment with the ability to work independently.
Proven demonstration of transparent communication and fostering open and diverse debate.
Personifies positive energy and exemplifies respect.

Nice To Haves

Experience in oncology or cancer biology preferred, but not required.
Development of physiologically relevant in vitro cell and tissue culture systems; primary cell culture considered a plus.
Experience driving screening funnels to evaluate candidate molecules through lead optimization workflows.
Flow cytometry.
Mechanism of action studies.

Responsibilities

Apply and develop cutting-edge tools and methodologies to enable advancement of company objectives with a focus on early discovery and lead optimization activities.
Find solutions to program-related challenges through project leadership and experimental activities.
Integrate with matrixed project teams.
Gather relevant information systematically, break down problems into simple components and make sound decisions.
Take on new challenges and build a culture of rigor and data-driven decision-making to bring novel therapies to the clinic.
Effectively communicate and collaborate with other R&D team members and collaborators to progress development candidate compounds.
Demonstrate high standards for scientific rigor, team behaviors, excellence and building a culture of innovation that is fully aligned with company objectives.
Demonstrate tenacity and drive for enterprise benefit.
Communicate and collaborate effectively.
Work with agility and manage ambiguity.