Scientist/Senior Scientist, Bioanalytical Sciences

Addition Therapeutics•South San Francisco, CA

1d•Onsite

About The Position

Addition Therapeutics is seeking a dynamic and highly motivated Scientist / Senior Scientist to join their Bioanalytical Sciences team. This role will focus on the development and execution of bioanalytical assays for preclinical translation and development, specifically evaluating proprietary PRINT™ technology in disease-relevant contexts. The successful candidate will contribute directly to key translational studies, generating high-quality data to guide candidate selection and advance therapeutic programs. This hands-on research role will involve working across obesity and metabolic disease programs, with a strong emphasis on preclinical drug development, including the development and execution of in vitro and ex vivo assays. The ideal candidate will be a collaborative and resourceful scientist with a keen interest in translational efforts to bring PRINT™ technology to the clinic for both rare and common diseases. This position offers significant learning opportunities and interaction with various company functions, including therapeutic technology development, pharmaceutical sciences, and preclinical translation, presenting a unique chance to explore the applications of PRINT™ and contribute to novel therapeutic programs.

Requirements

Ph.D. in molecular biology, biochemistry, pharmacology, cell biology, or a closely related field (relevant industry experience considered in lieu of Ph.D.)
Proficiency across standard molecular/biochemical assay platforms: ELISA, MSD, AlphaLISA, ddPCR, qPCR, Western blot, flow cytometry, and microscopy
Experience in mammalian cell culture to support cell-based assays
Ability to independently design experiments, troubleshoot, and interpret data
Clear and organized scientific communicator, comfortable presenting data to cross-functional audiences

Nice To Haves

Familiarity with obesity biology, metabolic disease, GPCR pharmacology.
Experience with genomic medicines, mRNA, or RNA-based therapeutic modalities
Exposure to NHP or translational PK/PD study design
Experience with animal models of disease is a plus
Familiarity with HTS or automated liquid handling platforms

Responsibilities

Design, develop, validate, and execute in vitro, cell-based, and ex vivo assays to evaluate the efficacy, pharmacology, and delivery of various payloads using PRINT™ technology.
Develop and execute pharmacodynamic assays to measure transgene expression, protein production and secretion, enzymatic activity, receptor engagement, and downstream biological responses.
Develop and run cell-based functional assays to evaluate therapeutic efficacy across obesity and other metabolic diseases.
Establish assays using primary cells, immortalized cell lines, and tissue-derived samples to support translational studies.
Collaborate with in vivo pharmacology teams to analyze plasma and tissue samples from rodent and non-human primate studies.
Ensure accurate and reliable results through meticulous hands-on execution and record-keeping.
Support PK/PD characterization by generating quantitative bioanalytical data to inform dose selection and mechanism of action.
Contribute to assay transfer, qualification, documentation, and implementation of best laboratory practices.
Collaborate with internal teams and partners to integrate and optimize current and new assay technologies and methodologies.
Analyze experimental data, interpret results, and present findings in team meetings. Contribute to troubleshooting and refining assay protocols.
Stay up to date with relevant scientific literature and emerging technologies. Provide input on potential improvements or innovations in assay development and genomic medicine applications.
Contribute to data packages supporting IND-enabling studies, partnership diligence, and investor milestones.