Senior Principal Scientist - Bioanalytical Sciences

Regeneron Pharmaceuticals•Tarrytown, GA

1d•$150,500 - $245,500•Onsite

About The Position

Regeneron's Assay Development Group (ADG) in Bioanalytical Sciences, located in Tarrytown, NY, is seeking a Senior Principal Scientist. In this exciting role, you will create and execute novel assay strategies for all biotherapeutic modalities, designing experiments, troubleshooting problems, organizing and interpreting experimental results and performing follow-up experiments. A Typical Day in the Role Might Look Like: Develop bioanalytical assay approaches for pharmacokinetic, biomarker assays and immunogenicity assays for a diverse pipeline of novel biotherapeutics, including monoclonal antibodies, bispecifics, antibody-drug conjugates (ADC), adeno-associated virus (AAV), CAR-T, RNA as well as drug target biomarkers to support non-clinical and clinical studies. Supervise a team of scientists in the development and validation of immunoassays for the measurement of drug, drug complexes and anti‑drug antibodies to support new programs. Guides the designs and execution of immunoassays (PK, PD and ADA) by direct reports, based on protocols provided by literature, seminars and other scientists. Suggests troubleshooting experiments for assay-related problems follow-up experiments to further assay development and optimize assays. Routinely reviews data for multiple developmental projects, working on these projects simultaneously. Summarizes and presents results internally to management and externally in industry meetings. Writes/reviews assay validation protocols, reports and SOPs prior to submission to Quality Auditing (QA). Functions as Study Director for assay validation studies conducted by direct reports.

Requirements

PhD degree with 5+ or a MS with 8+ or a BS with 10+ years meaningful experience.
An in-depth understanding of the science and technology on the development and validation of immunoassays is required.
The ability to perform sophisticated technical tasks to pursue projects that incorporate a diverse set of skills and work on multiple projects/experiments simultaneously is helpful.

Nice To Haves

Stimulates, develops, and promotes the scientific and career development of direct and indirect reports.
Can act as a leader within the group that effectively drives projects forward to meet aggressive timelines
Can communicate effectively with supervisor, upper management/senior leaders and other members within the company and/or outside vendors to obtain assay-related reagents or discuss reagents needs.
Propose innovative solutions and troubleshooting to address scientific complexity and challenges.

Responsibilities

Develop bioanalytical assay approaches for pharmacokinetic, biomarker assays and immunogenicity assays for a diverse pipeline of novel biotherapeutics, including monoclonal antibodies, bispecifics, antibody-drug conjugates (ADC), adeno-associated virus (AAV), CAR-T, RNA as well as drug target biomarkers to support non-clinical and clinical studies.
Supervise a team of scientists in the development and validation of immunoassays for the measurement of drug, drug complexes and anti‑drug antibodies to support new programs.
Guides the designs and execution of immunoassays (PK, PD and ADA) by direct reports, based on protocols provided by literature, seminars and other scientists.
Suggests troubleshooting experiments for assay-related problems follow-up experiments to further assay development and optimize assays.
Routinely reviews data for multiple developmental projects, working on these projects simultaneously.
Summarizes and presents results internally to management and externally in industry meetings.
Writes/reviews assay validation protocols, reports and SOPs prior to submission to Quality Auditing (QA).
Functions as Study Director for assay validation studies conducted by direct reports.