Scientist, Process Development

Alnylam Pharmaceuticals•,

1d•Onsite

About The Position

The Scientist, Process Sciences will be responsible for development, characterization and scale-up of biocatalytic processes. The successful candidate will work closely with cross-functional teams and contract manufacturing organizations on process development, process transfer, and oversight of oligonucleotide drug candidate manufacturing. This position is onsite and will be located at our Kendall Square offices in Cambridge, MA.

Requirements

Ph.D. in chemistry, chemical engineering, or biochemical engineering with 0-3 years or B.S./M.S. with 7+ years of relevant experience
Process research and development experience in applied biocatalysis
Demonstrated proficiency in the design and development of practical processes for manufacture of small molecules and oligonucleotides
Hands-on experience in process development and analytical methods for process and
Excellent organizational and communication skills
Demonstrated strong operational execution and problem-solving skills
Desire to work in a fast-paced, deadline-driven environment

Responsibilities

Contribute to process development, optimization, and scale-up of biocatalytic processes
Apply reaction engineering principles (mass transfer, mixing, kinetics, thermodynamics) to optimize process performance and scalability
Support the process and product characterization of small molecules and oligonucleotide APIs
Contribute to the management and optimization of in-house and contract manufacturing processes
Author and review technical protocols and development reports in support of manufacturing and process characterization activities
Author, edit, and review manufacturing documentation according to regulatory and procedural guidelines
Work closely with analytical development, manufacturing, QA, QC and CMO/CRO on the process transfer and process optimization
Contribute to strategic technical discussions and presenting progress at internal and external scientific meetings