Scientist I, Process Development

LGC Group•Petaluma, CA

19h•Onsite

About The Position

The Scientist in LGC Axolabs Process Development will be responsible for independent optimization of scale up/down solid-phase oligonucleotide synthesis, purification, concentration, conjugation, and downstream processing steps in preparation for handover to routine manufacturing. This role involves working with cross-functional teams to ensure successful execution of each campaign including troubleshooting technical issues. LGC Axolabs has an extensive, ever-evolving global client base along with impressive technical capabilities within a state-of-the-art GMP facility. As the needs for the organization continue to grow, we are seeking technically skilled and motivated candidates who can contribute to innovative solutions in oligonucleotide process development. The successful candidate will be detail-oriented, proficient in chemistry techniques, and capable of working independently while collaborating across teams to meet project goals. The Scientist will work under the guidance of a Lead Senior Scientist and/or the Process Development Manager and will interface with internal and external stakeholders.

Requirements

Bachelor’s degree or equivalent experience in Chemistry, Biology, or a related subject area with 4+ years of applicable experience, or Master’s degree or equivalent experience with 2+ years in a related field.
Strong communication skills, both written and verbal, to effectively collaborate with internal cross-functional teams and external partners.
Demonstrated dedication to scientific excellence and alignment with LGC’s core values and quality standards.
Proficiency in Microsoft Office, Outlook, Word, Filemaker Pro, IFS, and Excel.
Self-starter with strong problem-solving skills and the ability to work independently and with the broader team.

Nice To Haves

Technical understanding of oligonucleotide manufacturing processes and hands-on experience with relevant chemistry techniques, equipment, and methods.
Working knowledge of ChemDraw and Unicorn software (Synthesis and Purification).
Prior experience in a GMP-regulated environment within a CMO/CDMO or pharmaceutical manufacturing setting.

Responsibilities

Independent optimization and execution of all unit operations of custom oligonucleotide manufacturing including solid phase synthesis, cleavage and deprotection, preparative HPLC purification, conjugation chemistry, ultrafiltration/diafiltration, and lyophilization.
Sample preparation of samples to the Analytical Development Team.
Independently prepare solutions, samples, and instrumentation to support development procedures.
Advanced data interpretation and troubleshooting of process or instrumentation issues.
Collaborate with Senior Scientists in developing experimental designs and technical strategies.
Author SOPs and other analytical documents (e.g. Project Plan, QPP, TDR) with minimal oversight.
Basic understanding of relevant regulatory and pharmacopeia guidelines (FDA/ICH/USP) to ensure compliance in tech transfer activities.
Actively participates in internal & client-facing technical discussions.