Scientist, Pharmacokinetics

MSD • South San Francisco, CA

6d • $108,000 - $170,100 • Onsite

About The Position

The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) organization at our company's Research Laboratories is seeking a highly motivated and collaborative scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) group in South San Francisco (SSF). The Scientist will provide laboratory support for the multi-disciplinary drug discovery effort in SSF, with a focus on supporting preclinical development of therapeutics of various modalities through integrated understanding of drug disposition and pharmacology.
The scientist will work within a highly collaborative team and contribute to characterization of novel drug candidates in a range of therapeutic areas, including immunology, oncology, cardiovascular and metabolic disease, and ophthalmology. The scientist will be responsible for planning and conducting in vitro/ex vivo studies to evaluate the absorption, distribution, metabolism and excretion (ADME) properties of biologics, conjugates and other modalities. The ideal candidate will work with the team and interpret data, integrate, and clearly present results to help the team inform pipeline decisions. The candidate will also contribute to scientific initiatives for further advancing our knowledge of ADME and discovery bioanalytical science.

Requirements

• Bachelor's (with 3 years) or Master's in analytical science, biochemistry, biology, pharmaceutical sciences, chemistry, pharmacology, biochemical engineering, biophysics, or a related discipline and relevant experience
• Demonstrated experience with mammalian cell culture and performing cell-based assays
• Hands-on experience operating LC-MS/MS instrumentation, preferably SCIEX QQQ platforms, for quantitative bioanalysis
• Understanding of basic safety protocols, laboratory practices, and quality expectations in a research environment
• Bioanalysis
• Cell-Based Assays
• Cell Culture Techniques
• Laboratory Techniques
• Mammalian Cell Culture
• Mammalian Cell Lines
• Mass Spectrometry (MS)

Nice To Haves

• Previous experience in a research environment or/and in drug discovery and development
• Demonstrated experience with protein characterization using biochemical or biophysical techniques
• Previous experience with flow cytometry-based assays and analysis
• Previous experience developing or performing automated assays
• General knowledge of PK, ADME and/or drug discovery concepts is a plus not a must
• Demonstrated creativity and innovation via a publication/presentation record
• Proficient in using data analysis software, such as graphpad, excel, etc.
• Experience in using electronic notebooks is desirable
• Current Employees apply HERE
• Current Contingent Workers apply HERE
• US and Puerto Rico Residents Only
• San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
• Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance
• Search Firm Representatives Please Read Carefully
• Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Responsibilities

• Planning and conducting in vitro/ex vivo studies to evaluate the absorption, distribution, metabolism and excretion (ADME) properties of biologics, conjugates and other modalities.
• Interpreting data, integrating, and clearly presenting results to help the team inform pipeline decisions.
• Contributing to scientific initiatives for further advancing our knowledge of ADME and discovery bioanalytical science.

Benefits

• medical, dental, vision healthcare and other insurance benefits (for employee and family)
• retirement benefits, including 401(k)
• paid holidays
• vacation
• compassionate and sick days

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Associate degree