Scientist, Pharmacokinetics

Merck•South San Francisco, CA

5d•$108,000 - $170,100•Onsite

About The Position

The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) organization at our company's Research Laboratories is seeking a highly motivated and collaborative scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) group in South San Francisco (SSF). The Scientist will provide laboratory support for the multi-disciplinary drug discovery effort in SSF, with a focus on supporting preclinical development of therapeutics of various modalities through integrated understanding of drug disposition and pharmacology. The scientist will work within a highly collaborative team and contribute to characterization of novel drug candidates in a range of therapeutic areas, including immunology, oncology, cardiovascular and metabolic disease, and ophthalmology. The scientist will be responsible for planning and conducting in vitro/ex vivo studies to evaluate the absorption, distribution, metabolism and excretion (ADME) properties of biologics, conjugates and other modalities. The ideal candidate will work with the team and interpret data, integrate, and clearly present results to help the team inform pipeline decisions. The candidate will also contribute to scientific initiatives for further advancing our knowledge of ADME and discovery bioanalytical science. The successful candidate should have hands-on experience with in vitro and ex vivo cellular assays to characterize biologics and conjugates, as well as LC-MS/MS-based bioanalytical methodologies. Experience handling biological matrices and developing quantitative assays for drug and biomarker measurements is highly desirable. The scientist must be highly motivated, able to work collaboratively in a fast-paced environment, and possess excellent scientific, interpersonal, and communication skills.

Requirements

Bachelor's (with 3 years) or Master's in analytical science, biochemistry, biology, pharmaceutical sciences, chemistry, pharmacology, biochemical engineering, biophysics, or a related discipline and relevant experience
Demonstrated experience with mammalian cell culture and performing cell-based assays
Hands-on experience operating LC-MS/MS instrumentation, preferably SCIEX QQQ platforms, for quantitative bioanalysis
Understanding of basic safety protocols, laboratory practices, and quality expectations in a research environment
Bioanalysis
Cell-Based Assays
Cell Culture Techniques
Laboratory Techniques
Mammalian Cell Culture
Mammalian Cell Lines
Mass Spectrometry (MS)

Nice To Haves

Previous experience in a research environment or/and in drug discovery and development
Demonstrated experience with protein characterization using biochemical or biophysical techniques
Previous experience with flow cytometry-based assays and analysis
Previous experience developing or performing automated assays
General knowledge of PK, ADME and/or drug discovery concepts is a plus not a must
Demonstrated creativity and innovation via a publication/presentation record
Proficient in using data analysis software, such as graphpad, excel, etc.
Experience in using electronic notebooks is desirable
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance
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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are place, introductions are position specific. Please, no phone calls or emails.

Responsibilities

Planning and conducting in vitro/ex vivo studies to evaluate the absorption, distribution, metabolism and excretion (ADME) properties of biologics, conjugates and other modalities.
Interpreting data, integrating, and clearly presenting results to help the team inform pipeline decisions.
Contributing to scientific initiatives for further advancing our knowledge of ADME and discovery bioanalytical science.