Scientist, Peptide Chemistry (Night Shift)
About The Position
We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber. We value speed and rigor, coupled with excitement, drive, and a strong work ethic. In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy. Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better. You will be surrounded by people who care intensely about the work, get close feedback from the people making scientific and company-defining decisions, and have room to own increasingly important problems. We believe excellent work should be met with meaningful reward, ownership, and trust. Responsibility is earned through contribution, not title alone: anyone who demonstrates the judgment, rigor, and follow-through to move important work forward can earn meaningful scope. About the Role You will run peptide-synthesis workflows on a dedicated night-shift schedule so compounds are ready for characterization, biological testing, or handoff the next day. You will own careful overnight execution, troubleshoot issues independently, maintain complete records, and give the day team a clear account of every batch, result, and open question.
Requirements
- Able and willing to work the designated night-shift schedule reliably and operate independently when needed.
- Hands-on chemistry or biochemistry laboratory experience and strong experimental discipline.
- Interest in owning the overnight synthesis workflow from reaction execution through purification, characterization, documentation, and sample handoff.
- A fast, rigorous, and safety-conscious approach to laboratory work.
- Proactive judgment when an instrument breaks, a synthesis fails, data look unusual, or a handoff needs clarification.
Nice To Haves
- Experience with solid-phase peptide synthesis, HPLC, prep HPLC, or LC-MS is valuable, but we can teach specific workflows.
Responsibilities
- Execute overnight peptide synthesis workflows, including resin loading, coupling and deprotection cycles, cleavage, purification, characterization, and sample preparation.
- Run microwave-assisted solid-phase peptide synthesis and support routine synthesizer maintenance during night-shift hours.
- Troubleshoot failed couplings, low crude purity, side products, cleavage issues, and instrument downtime.
- Purify and characterize candidates using analytical HPLC, prep HPLC, LC-MS, and related methods.
- Record identity, purity, yield, analytical traces, and batch-level quality-control data for morning handoff.
- Prepare compounds for in vitro and in vivo testing and maintain accurate experimental records.
- Provide clear handoffs covering completed work, failures, results, sample locations, risks, and follow-up actions.
Benefits
- Generous equity options
- $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.
- Medical, dental, and vision coverage options, with Capable covering 100% of the base policy.
- HSA, FSA, and 401K plans.
- Healthy dinners with the team are provided daily.
- Visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
No Education Listed
