Scientist, Organic Chemistry (Night Shift)

Capable Labs • San Francisco, CA

2d • Onsite

About The Position

We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber. We value speed and rigor, coupled with excitement, drive, and a strong work ethic. In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy. Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better. You will be surrounded by people who care intensely about the work, get close feedback from the people making scientific and company-defining decisions, and have room to own increasingly important problems. We believe excellent work should be met with meaningful reward, ownership, and trust. Responsibility is earned through contribution, not title alone: anyone who demonstrates the judgment, rigor, and follow-through to move important work forward can earn meaningful scope.

Requirements

• Able and willing to work the designated night-shift schedule reliably and operate independently when needed.
• Hands-on synthetic chemistry experience and strong experimental discipline.
• Interest in owning overnight chemistry from reaction execution through purification, characterization, documentation, and sample handoff.
• A creative, fast, rigorous, and safety-conscious approach to laboratory problem-solving.
• Sound judgment when a reaction fails, an instrument is down, data look unusual, or the usual day-team contact is unavailable.
• The ability to maintain excellent records and create clean, useful handoffs across night and day teams.

Responsibilities

• Execute overnight synthesis workflows, including route planning, reaction setup, workup, purification, characterization, and sample preparation.
• Run and troubleshoot organic reactions involving functional-group transformations, coupling chemistry, protecting-group strategies, late-stage diversification, and parallel synthesis.
• Use solution-phase and solid-phase methods where appropriate, including cleavage, deprotection, crude analysis, purification, and final quality control.
• Resolve overnight issues involving low conversion, poor selectivity, side products, decomposition, solubility, purification, recovery, and instrument downtime.
• Purify and characterize compounds using analytical HPLC, prep HPLC, LC-MS, NMR, flash chromatography, SFC, and related methods as appropriate.
• Prepare compounds for in vitro and in vivo testing and maintain accurate experimental and batch-level quality-control records.
• Provide clear morning handoffs covering completed work, results, failures, sample locations, risks, and follow-up actions.

Benefits

• Generous equity options
• $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.
• Medical, dental, and vision coverage options, with Capable covering 100% of the base policy.
• HSA, FSA, and 401K plans.
• Healthy dinners with the team are provided daily.
• Visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: No Education Listed