Scientist, Oncology Discovery (Multi-Specific Antibody Therapeutics)

Pfizer • San Diego, CA

15h • Onsite

About The Position

As a Scientist in the Discovery Technologies department, you will contribute directly to early‑stage programs focused on discovery of next generation biologics for oncology. Your work will generate high-impact functional screening data that guides antibody discovery decisions, informs lead molecule selection, and enables portfolio progression of transformative therapeutics.

Requirements

• BS or MS in Biology, Molecular Biology, Cell Biology, Biochemistry, Immunology, or a related discipline
• BA/BS with at least 6 years of experience or MBA/MS with at least 4 years of experience working with antibody-based therapeutics in biotechnology or pharmaceutical settings.
• Hands‑on experience with cell‑based functional assays , particularly those assessing immune cell function (e.g., T cell cytotoxicity assays)
• Demonstrated proficiency in mammalian cell culture , including cancer cell lines and primary immune cells
• Experience executing assays in high‑throughput or semi‑automated formats , including familiarity with laboratory automation and 384-well plate assay formats
• Strong data analysis, organization, and documentation skills
• Excellent written and verbal communication skills and the ability to work productively in cross‑functional teams
• Ability to adapt quickly in a fast‑paced, discovery‑driven research environment
• Permanent work authorization in the United States.

Nice To Haves

• Experience with molecular biology techniques , including cloning, transfection, lentivirus production, and cell line engineering
• Familiarity with biochemistry/biophysical analytical techniques used to characterize antibodies and other biologic therapeutics (SPR, HPLC, Mass spectrometry)
• Experience with Genedata platforms (Biologics, Screener) or similar

Responsibilities

• Design, develop, and execute high-throughput cell‑based functional assays in support of multi‑specific antibody and T cell engager discovery programs
• Perform assays measuring target engagement, cell binding, T cell-mediated cytotoxicity of tumor cells, and T cell activation in the presence of antibody therapeutics; with flow cytometry, luminescence, NanoBRET, and HTRF-based readouts
• Culture and maintain cancer cell lines and primary human T cells in vitro
• Generate and engineer cell lines using molecular cloning, transfection, lentivirus production, and transduction
• Implement and support high‑throughput and semi‑automated assay workflows , including use of Echo liquid handling systems and 384-well plate assay formats
• Analyze, interpret, and clearly communicate experimental data to project teams
• Effectively manage, curate, and structure experimental data to maintain high-quality documentation in electronic lab notebooks and enable integration with an AI-ready environment
• Collaborate effectively within cross‑functional teams spanning tumor biology, protein engineering, automation, and data sciences

Benefits

• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
• paid vacation, holiday and personal days
• paid caregiver/parental and medical leave
• health benefits to include medical, prescription drug, dental and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Senior