Scientist – Oligonucleotide/Peptide

IntelliPro Group Inc.•Cambridge, MA

1d•Onsite

About The Position

We are seeking a highly motivated and creative individual with some process development experience to join our Oligonucleotide/Peptide Purification Development team. This position provides an exciting opportunity to develop robust, high purity, state of the art processes for the purification of oligonucleotides. This position provides an exciting opportunity to gain hands-on experience and exposure to the design and development of manufacturing processes for clinical and commercial therapeutics. We are looking for someone who is passionate for exploring novel scientific ideas and play a key role in developing new cutting-edge technologies with a vision to push client’s state-of-art science in oligonucleotide and peptide purification that can ultimately impact patient lives.

Requirements

Bachelor’s degree in Biochemistry, Chemical Engineering, Chemistry, or related life science field with 2-4 years industry experience (or master’s degree with 0-2 years of industry experience) is required.
Bachelor’s degree in Biochemistry, Chemical Engineering, Chemistry or related life science field with 4 years industry experience (or master’s degree with 2 years of industry experience) is required.
Proven record of successfully planning and executing projects and experiments.
Excellent verbal and written communication skills.
Demonstrated technical proficiency and creativity in developing innovative technologies/approaches in purification.
Excellent organizational, communication, and time management skills.
Lab experience in purification of proteins, peptides and/or DNA/RNA using column chromatography (e.g., Ion exchange, Hydrophobic Interaction, and/or Reversed phase) and UF/DF.
Some hands-on experience in analysis of proteins, peptides or DNA/RNA, preferably using both HPLC and UV/Vis spectroscopy.
Motivated to work and communicate both individually and within teams

Nice To Haves

Experience using AKTA purification systems and Unicorn software
Use of statistical design (DoE) are a plus.
Experience in statistical analysis is also a plus.

Responsibilities

Develop and characterize purification processes for a rapidly expanding pipeline of new oligonucleotides and peptide drug therapies.
Utilize multiple modes of chromatography and ultrafiltration and learn chemical cleavage/conjugation/hybridization steps.
Investigate new purification technologies that seek to enhance purity, process robustness and/or productivity of our existing oligonucleotide platform process.
Collaborate cross-functionally with other groups to improve process understanding and manage team activities.
Document laboratory work in development reports, training/mentoring of new employees, and lead pilot scale activities.
Scale-up and technology transfer oligonucleotide processes into our pilot and GMP manufacturing facilities and participate in writing regulatory sections for INDs.