Senior Scientist, Peptide Display Technologies

Novartis•San Diego, CA

1d•Onsite

About The Position

We are seeking a highly motivated Senior Scientist to join the Exploratory Chemical Biology team within the Novartis Biomedical Research in San Diego. The successful candidate will contribute to the discovery of LMW, peptide, and protein therapeutics through the application of modern display technologies and molecular engineering approaches. This position provides a unique opportunity to work at the interface of chemical biology, protein engineering, and emerging therapeutic modalities. The successful candidate will support discovery programs through the design and execution of display selections, library constructions, molecular characterizations, and data analyses in a highly collaborative research environment. Key Responsibilities: Design and execute peptide and protein discovery campaigns using phage, mRNA, yeast, and other display or selection platforms. Generate, characterize, and quality-control combinatorial libraries using cloning, PCR, DNA assembly, mutagenesis, and sequencing. Identify and optimize discovery candidates through iterative selection, molecular engineering, and biochemical or biophysical characterization using ELISA, flow cytometry, BLI, SPR, and related technologies. Analyze data and clearly communicate findings to project teams. Implement new technologies, workflows, and automation approaches to improve discovery efficiency.

Requirements

BS, MS, or recent PhD (within last 2 years) in Molecular Biology, Biochemistry, Biotechnology, Chemical Biology, Bioengineering, or a related field, with 4+ years of relevant experience or training.
Drug discovery experience preferred.
Hands-on experience with display technologies (phage, yeast, and/or mRNA), screening and assay technologies, and molecular biology methods, including library construction and quality control, PCR, cloning, electroporation, and DNA assembly.
Strong laboratory skills, attention to experimental detail, and accurate, timely documentation in electronic laboratory notebooks.
Strong organizational and prioritization skills, with the ability to manage multiple tasks and deliver results within established timelines.
Excellent written and verbal communication and interpersonal skills, with a demonstrated ability to work effectively in a diverse, collaborative team.

Responsibilities

Design and execute peptide and protein discovery campaigns using phage, mRNA, yeast, and other display or selection platforms.
Generate, characterize, and quality-control combinatorial libraries using cloning, PCR, DNA assembly, mutagenesis, and sequencing.
Identify and optimize discovery candidates through iterative selection, molecular engineering, and biochemical or biophysical characterization using ELISA, flow cytometry, BLI, SPR, and related technologies.
Analyze data and clearly communicate findings to project teams.
Implement new technologies, workflows, and automation approaches to improve discovery efficiency.