Scientist – Off-Target Genomics (Gene Therapy)
About The Position
At Eurofins Professional Scientific Services (PSS), we are committed to supporting your professional growth by providing opportunities to enter and advance within the biopharmaceutical industry. Our teams are collaborative and supportive, offering the tools and environment needed to succeed while maintaining work-life balance and a competitive benefits package. Eurofins Scientific is a global leader in life sciences, delivering a broad range of analytical testing services across industries including pharmaceuticals, food, environmental, and clinical research. Our work helps ensure product safety, quality, and compliance, contributing to a healthier and more sustainable world. We are seeking a Scientist – Off-Target Genomics (Gene Therapy) to lead and execute genomic safety assessment strategies for gene editing therapeutics. This role focuses on evaluating off-target effects, genomic integrity, and emerging genome editing modalities.
Requirements
- B.S. with 5+ years, M.S. with 3–7 years, or Ph.D. with 2–4 years of industry experience in genomics, molecular biology, biochemistry, or a related field
- Hands-on experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics
- Strong working knowledge of CRISPR-based genome editing technologies
- Experience with next-generation sequencing workflows and data interpretation
- Familiarity with base editing, prime editing, and associated genotoxicity considerations
- Demonstrated scientific problem-solving skills
- Strong communication skills with the ability to present complex data to diverse audiences
- Self-motivated, adaptable, and able to work both independently and collaboratively
Nice To Haves
- Assay development experience is a plus
- Experience with optical genome mapping (e.g., Bionano platform)
- Understanding of regulatory expectations for genomic safety (IND/BLA submissions)
- Exposure to human diversity-informed off-target methods (e.g., ONE-seq)
Responsibilities
- Lead genomic safety assessment packages, including off-target discovery, verification, validation, and genomic integrity characterization
- Apply and evaluate off-target discovery approaches using: In silico tools (e.g., CALITAS, CRISPRme, Cas-OFFinder), Biochemical methods (e.g., SITE-seq, CIRCLE-seq, CHANGE-seq, Digenome-seq), Cell-based assays (e.g., GUIDE-seq, INDUCE-seq)
- Drive off-target confirmation using sequencing-based approaches such as AmpSeq, rhAmpSeq, and hybrid capture
- Assess genomic integrity using orthogonal platforms including karyotyping, optical genome mapping, and whole genome sequencing (WGS)
- Evaluate genotoxicity risks associated with next-generation genome editing technologies, including base and prime editing
- Support and/or lead development of novel assays for emerging genome editing modalities (Gen 5+)
- Integrate biodistribution data to inform tissue selection for off-target verification studies
- Collaborate cross-functionally and present findings clearly to scientific and project teams
Benefits
- Comprehensive medical coverage
- Dental options
- Vision options
- Life insurance
- Disability insurance
- 401(k) with company match
- Paid vacation
- Paid holidays
- Yearly goal-based bonus
- Eligibility for merit-based increases
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
No Education Listed
