Scientist, Medicinal Chemistry

General Proximity • San Francisco, CA

15h • Onsite

About The Position

General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades. We are seeking a first-rate medicinal chemist to help us pioneer this uncharted frontier of drug discovery. A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition, but there are many other possible perturbation types whose potential remains unrealized. General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach). Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines, and our technology holds the same promise. We are seeking a medicinal chemist to be a member of our Chemistry/Drug Discovery Team. In this position, you will work with both our Chemistry and Platform Teams in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.

Requirements

• PhD in Medicinal Chemistry, Chemical Biology, Pharmacology, or related field.
• Industry experience is desirable, but the ability to work hard and learn fast is more important to us.
• Deep understanding of small-molecule drug discovery and its relationship to human disease.
• Able to work fluently at the interface of chemistry and biology.
• Top-notch written and oral communication skills.
• Strong experience in Design, synthesis, and optimization of induced proximity medicines (e.g. PROTACs or other IPMs)
• Hit-to-lead and lead optimization campaigns
• Multi-step organic synthesis, with a proven ability to design and execute complex synthetic routes toward drug-like small molecules
• Medicinal chemistry optimization: SAR, PK/PD, and strong working knowledge of DMPK principles
• Chemical biology techniques including mammalian cell culture, cell-based assays (e.g., cytotoxicity, transfections, stable cell line generation, co-IP), and PPI assays (e.g., BRET, APEX/BioID, AlphaScreen); computational chemistry experience also welcomed

Nice To Haves

• HTS and phenotypic assay development
• Proteomics experience: PTM analysis, chemo-proteomic target deconvolution, etc.
• Computational or molecular dynamics drug discovery experience
• DEL experience
• Experience managing synthetic chemistry CRO teams
• Prior experience on teams that have successfully advanced research to the clinic

Responsibilities

• Designing and optimizing first-in-class bifunctional molecules
• Assessing SAR to inform iterative medicinal chemistry optimization
• Supervising synthetic efforts with CRO partners
• Performing and analyzing in cellulo assays
• Collaborating with our Drug Discovery and IP teams on patent applications
• Contributing mechanistic insight on lead drug molecules

Benefits

• Strong equity incentives
• Top tier medical, dental, and vision coverage + One Medical membership
• 401(k) retirement plans
• Education and health/fitness incentive programs
• Meditation retreats—do a ten-day Vipassana retreat without counting towards vacation days.
• Reading budget! We will buy you books.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree