Senior Associate Scientist, Medicinal Chemistry

Alnylam Pharmaceuticals•Cambridge, MA

3d•$80,000 - $120,000•Onsite

About The Position

We are seeking a talented and passionate scientist to join our dynamic, fast-paced, and collaborative team. Using strong organic synthesis skills, you will contribute to developing and supporting novel chemistry solutions for the advancement of our RNAi platform. The successful candidate will have a strong background in synthetic Organic Chemistry with a creative mindset, independent problem-solving ability, and desire to enable discoveries at the bench. This position is onsite and will be primarily located in Cambridge, MA.

Requirements

B.S./M.S. in Chemistry
2-3 years of industrial experience in Medicinal Chemistry
Demonstrated ability to understand reaction mechanism and chemical reactivity in Organic Chemistry
Strong laboratory skills in synthesis, purification, and characterization of small molecules
Expertise in state-of-the-art analytical techniques such as LC, MS, NMR, and the ability to analyze, interpret, and present data
Must be flexible to be able to apply her/his knowledge to new areas of study
Thrive in a team environment
Possess excellent communication skills (both written and oral)

Responsibilities

Develop and execute syntheses of novel chemical modifications and delivery modalities for siRNA
Multi-step synthesis, purification, and structural analysis of intermediate compounds
Synthesis of organic building blocks to be used for RNA delivery
Work closely with our internal RNAi platform teams and external collaborators to discuss project plans and coordinate activities for delivery and activity determination of siRNA
Troubleshoot and perform routine maintenance on critical instrumentation such as NMR, HPLC, LCMS and other instruments in the lab
Analyze, interpret, and organize data to prepare clearly articulated experimental reports and communicate the results of the projects at internal meetings