Scientist, Lead Generation Biology – Antibody & Biomolecular Interactions

Neurocrine Biosciences • San Diego, CA

4d • Onsite

About The Position

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. We are looking for a highly qualified and collaborative Scientist to join our Lead Generation Biology team. This role involves working across multiple functional teams to develop, qualify, and perform MSD immunoassays, flow cytometry, and cell-based assays to screen, characterize, and identify lead biologic therapeutic and platform candidates. The position requires excellent scientific, technical, and laboratory experience and skills, with strong organizational and communication skills to effectively interact across teams in delivering high-quality, fit-for-purpose, decision-making data to project teams. The individual will be responsible for documenting protocols and regularly presenting clear written and verbal data summaries. The work is fast-paced and process-oriented in an environment where efficiency and continuous improvement are integral goals.

Requirements

• BS/BA degree in scientific field and 2+ years of in vitro pharmacology experience
• Primary cell culture, especially CNS, and related assay development
• Liquid handling automation and LIMS systems
• GPCRs and related in vitro assays
• Independently plan, develop, and execute basic experiments with ability to own the process from end-to-end
• Apply independent thinking to solve problems with consistency
• Good knowledge of scientific principles, methods, techniques, and demonstrated ability to work with a variety of laboratory equipment/tools
• Takes direction regarding experiments or lab processes and learns to apply independent thinking to resolve technical issues
• Understand how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals
• Ability to work as part of a team as a trusted and impactful scientific and technical collaborator and contributor
• Ability to meet deadlines with high-quality and impactful results
• Detail oriented with good organization, communication, problem-solving, analytical thinking skills
• Good project management skills

Nice To Haves

• MS/MA degree in scientific field and some relevant industry experience
• PhD in biology or related field
• Some experience with cell culture and cell-based in vitro assays
• Development and optimization of in vitro biological assays
• Familiar with common data analysis methods and software, such as Prism, Spotfire, Microsoft Office, ELN, etc.

Responsibilities

• Design and develop fit-for-purpose immunoassays to evaluate in vitro and ex vivo samples for relevant analytes in a non-regulated environment to support antibody discovery and platform programs.
• Apply bioanalytical principles to assay development and qualification aligned with intended use.
• Use strong scientific insight to guide method development, in collaboration with project, translational, and in vivo teams to generate key data to drive decisions for therapeutic and platform programs.
• Screen diverse antibody panels to advance programs through critical stage gates by generating and delivering high-quality, relevant data.
• Use expertise in immunoassays, BLI, cell-based assays, and/or flow cytometry to design and implement impactful assays in collaboration with project teams.
• Apply scientific and technical knowledge, along with an understanding of project objectives, to identify relevant, translatable, and fit-for-purpose methods that support lead candidate selections.
• Employ best practices in data and statistical analysis, QC and documentation to support generation of high-quality, reproducible, and physiologically relevant data.
• Work independently and within cross-functional teams to manage and deliver on multiple projects without compromising data quality.
• Leverage strong time-management and organizational skills, with scientific expertise, to understand project needs and deliver timely results that support team objectives.
• Train junior scientists to efficiently deliver on team goals.

Benefits

• Retirement savings plan (with company match)
• Paid vacation
• Holiday and personal days
• Paid caregiver/parental and medical leave
• Health benefits to include medical, prescription drug, dental and vision coverage

What This Job Offers

• Job Type: Full-time
• Career Level: Senior