Scientist, Large Molecule Analytical (On-site)

MSD•Rahway, NJ

2d•Onsite

About The Position

The Large Molecule Analytical department within the Research & Development Division is seeking a laboratory-based Scientist to solve complex analytical problems at the interface of biology, chemistry, and laboratory informatics, supporting development of biologics drug substances and drug products. The successful candidate will work collaboratively in a fast-paced, integrated, multidisciplinary team. The role is responsible for developing, qualifying, implementing, troubleshooting, and transferring analytical methods for monoclonal proteins and other complex therapeutic proteins. The candidate should bring strong organizational, multitasking, and communication skills, scientific leadership, and an interest in conducting research and publishing. The primary location is Rahway, New Jersey. The role is onsite, on the first (day) shift, with 10% travel. Relocation is domestic; visa sponsorship is not available. The position is listed as regular employee status.

Requirements

BA/BS in analytical chemistry, biochemistry, or a related field, with at least 3 years of pharmaceutical industry experience; or an M.S. with at least 0 years of relevant experience. For the M.S. route, expected graduation must be no later than January 2027.
Prior experience in a laboratory environment.
Ability to apply basic principles and scientific concepts to execute work in a laboratory setting.
Ability to execute routine experiments and interpret data with appropriate technical guidance.
Ability to operate and troubleshoot analytical methods.
Understanding of the fundamentals of separations science.
Experience with UPLC/HPLC analysis of biologics, such as SEC, RP, or IEX, and CE techniques; alternatively, experience with molecular biology techniques such as PCR and DNA extraction, and immunoassay techniques such as ELISA and gel electrophoresis.
Ability to manage prioritization and execution of individual deliverables within project timelines with appropriate supervision.
Demonstrated experience working in collaborative team environments.
Experience authoring and reviewing internal technical reports, sections of regulatory filings such as INDs or BLAs, and external scientific publications.
Effective organizational, multitasking, and oral and written communication skills.
Laboratory skills and knowledge associated with analytical chemistry, analytical development, biological analysis, biologics, cell-based assays, DNA extractions, GMP, immunoassays, laboratory automation, LIMS, laboratory techniques, mammalian cell culture, qPCR, and SOP writing.

Nice To Haves

Evidence of strong cross-functional collaboration in an academic or industrial setting.
Past experience working as part of a project team.
Strong knowledge of protein structure and degradation pathways.
Experience analyzing various biologic modalities, such as monoclonal antibodies, antibody-drug conjugates, and fusion proteins.
Background in analytical methodologies and a sound scientific understanding of Critical Quality Attributes, QbD, and DOE principles.
Prior experience with Microsoft Office and research applications such as RLIMS, ELN, and Empower.
Experience in data analytics, programming, or laboratory automation.

Responsibilities

Develop, qualify, implement, troubleshoot, and transfer analytical methods for monoclonal proteins and other complex therapeutic proteins.
Solve complex analytical problems involving biology, chemistry, and laboratory informatics to enable development of biologics drug substances and drug products.
Execute routine laboratory experiments and interpret data with appropriate technical guidance.
Operate and troubleshoot analytical methods.
Manage prioritization and execution of individual deliverables within overall project timelines and with appropriate supervision.
Author and review internal technical reports, sections of regulatory filings such as INDs and BLAs, and external scientific publications.
Collaborate in a fast-paced, integrated, multidisciplinary team environment.