Analytical Scientist, Large Molecule

Elanco • Indianapolis, IN

3d • Hybrid

About The Position

As an Analytical Scientist – Large Molecule, you will be part of Elanco’s R&D organization, developing, optimizing, and implementing chromatographic, electrophoretic, and mass spectrometry analytical methods for biopharmaceutical products. You will advance analytical techniques for therapeutic proteins and vaccines, support bioprocess development, and lead method validation, qualification, and transfer across global internal manufacturing sites and external CRO/CDMO partners.

The role includes working with interdisciplinary teams across Discovery Research, Bioprocess Development, Formulation, and Quality; mentoring junior scientists and technical associates; and producing technical documentation and regulatory summaries. The position is based at Elanco’s Global Headquarters in Greenfield, Indiana, with a hybrid arrangement involving laboratory-based work and flexible office arrangements. Travel may be up to 10% annually for technical site visits and cross-site transfers.

Requirements

• Bachelor’s degree in Analytical Chemistry, Biochemistry, Biophysics, Chemical Engineering, or a related scientific discipline.
• At least 5 years of relevant hands-on biotechnology or biopharmaceutical industry experience focused on large-molecule characterization.
• Demonstrated experience developing and validating HPLC/UPLC-based, electrophoretic, and LC/MS analytical methods for biologics.
• Strong scientific problem-solving abilities and excellent written and verbal communication skills.

Nice To Haves

• Experience characterizing recombinant proteins, monoclonal antibodies, oligonucleotides, and therapeutic peptides.
• Experience leading method validation, qualification, and transfer in a cGMP-regulated environment.
• Proficiency with Design of Experiments, statistical analysis, and statistical software such as JMP.
• Hands-on experience with Electronic Laboratory Notebook platforms and chromatography data systems such as Empower.
• Ability to independently design, prioritize, and execute complex scientific studies while navigating evolving project priorities.
• Familiarity with the Animal Health regulatory framework, including USDA/FDA.

Responsibilities

• Design, develop, and optimize chromatographic methods, including SEC, RP-HPLC, IEX, and HIC, electrophoretic methods, including CE-SDS and icIEF, and LC/MS methods such as intact mass and peptide mapping for therapeutic protein and vaccine candidates.
• Develop and implement analytical solutions to support drug formulations, stability studies, and upstream and downstream bioprocess development.
• Lead analytical method validation, verification, qualification, and technical transfer activities across Elanco sites and CRO/CDMO partners.
• Ensure analytical methods, protocols, and documentation comply with data integrity standards and GMP/regulatory expectations.
• Train, guide, and mentor junior scientists and technical associates.
• Serve as the analytical subject matter expert on interdisciplinary project teams, collaborating with Discovery Research, Bioprocess Development, Formulation, and Quality teams.
• Author and review technical reports, method SOPs, validation protocols, and regulatory submission summaries.
• Maintain thorough ELN documentation and uphold laboratory safety and quality standards.

Benefits

• Competitive paid time off and two week-long U.S. company-wide shutdowns, in summer and at year-end.
• Up to 6% 401(k) company matching.
• Annual performance bonus eligibility.
• Eight weeks of fully paid parental leave.
• Flexible work arrangements.
• Relocation packages available for eligible candidates.
• Access to 9 active global Employee Resource Groups.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior