Scientist, In Vivo Process Development Downstream
About The Position
The Scientist, In Vivo Process Development Downstream role designs and executes downstream/purification experiments to support development of manufacturing processes for Lentivirus. This role applies advanced chemistry, biochemistry, and/or engineering principles to deliver robust, scalable processes, supports manufacturing activities and process optimization at scale, and operates with broad autonomy and limited oversight. The Scientist is accountable for end-to-end process performance, scientific soundness, and technical leadership while training and mentoring colleagues.
Requirements
- Must have strong scientific understanding and demonstrated hands-on proficiency of downstream unit operations for large biomolecules (e.g. protein, virus) such as chromatography and filtration.
- Sound understanding of bioprocess scale-up principles for large biomolecules
- Working knowledge of cGMP principles
- Proficiency in Microsoft Word, Excel, Power Point, and data analysis software such as JMP, GraphPad
- Proven ability to collaborate in a dynamic team environment
- Excellent interpersonal, verbal, and written communication skills
- Strong organization and problem-solving skills with excellent attention to details
Nice To Haves
- Prior experience with process development of viral vectors
- Prior experience with the use of Design of Experiments (DOE) to support process development experiments.
- Prior experience with fermentation/cell culture and analysis of large biomolecules
- Hands-on experience with large scale bioprocessing in either non-GMP or GMP setting
- Demonstrated mentorship and team leadership
Responsibilities
- Design and optimize scalable, safe, and cost-effective downstream process for Lentivirus manufacturing.
- Develops technical solutions to complex problems requiring ingenuity and creativity, applying advanced scientific/engineering principles to ensure scientific soundness and performance.
- Supports manufacturing activities and process optimization at scale, contributing technical expertise to improve process performance and scalability.
- Manages day-to-day laboratory operations, including planning work, maintaining efficient lab execution, and ensuring effective documentation practices.
- Keep accurate, detailed laboratory records and comply to all required training and safety guidelines.
- Apply statistical methodologies and basic modelling approaches to design experiments, perform data analysis, and interpret data.
- Trains, guides, and mentors colleagues by sharing technical skills, coaching on process execution, and troubleshooting, and strengthening team capability.
- Communicates technical outcomes in technical reports and presentations
- Interface with multidisciplinary groups to solve complex issues and promote collaboration.
- Works independently with broad autonomy and limited oversight; determines approaches for moderately complex assignments under minimal direction.
Benefits
- company-sponsored medical, dental, vision, and life insurance plans
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
