Contract Role - Scientist, Immunology - San Diego, CA

Mirador Therapeutics, Inc.•San Diego, CA

1d•$105,000 - $115,000•Onsite

About The Position

Mirador Therapeutics, Inc. is a clinical-stage precision medicine company focused on developing first-and/or best-in-class next-generation therapeutics for immunology and inflammation. The company’s Mirador360™ precision development engine leverages the latest advances in human genetics and data science to rapidly deliver new precision medicines for patients living with immune-mediated inflammatory and fibrotic diseases. Mirador has raised over $650 million from leading life sciences investors and is based in San Diego, CA. Mirador was named Best Places to Work by Biospace and is a Great Place to Work-Certified™ Company. We are seeking a motivated, versatile, detail-oriented Contractor who will work with the Immunology Team. This Contract Scientist role will focus on preclinical and IND-enabling in vitro studies. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment.

Requirements

Bachelor’s degree with 6 years or more or Master’s degree with 4 years or more relevant biotech and/or pharmaceutical industry experience.
Experience with molecular/ cell biology techniques such as CRISPR, RT-PCR, cell transfection, cell line generation are required.
Experience using MSD, Luminex and ELISA to measure analytes in serum, plasma, supernatant or cell lysates is required.
Experience developing ex-vivo models to assess immune responses from human whole blood, PBMCs, and various immune cell subsets.
Experience with cell-based assays including primary cell and reporter cell assays.
Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues is required.
Experience with Western Blots for samples generated from cell pellets and tissue.
Experience with protein quantification techniques from tissue samples.
Proficiency in data analysis using Excel, GraphPad Prism, and Flow Jo is required.

Nice To Haves

Experience with transcriptomics studies (e.g., RNAseq, nanostring) are a plus.
Experience with tissue explants and organoid systems is a plus.

Responsibilities

Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development.
Work on preclinical and IND-enabling in vitro studies.
Analyze, critically interpret data and share results to project teams as required.
Keep meticulous records of experiments performed and maintain ELN entries.
Work collaborative with other scientists in the group in a highly matrixed lab environment.