Scientist II - LC-MS/MS Bioanalysis (Method Development)

KCAS Bio • Kansas City, MO

3d

About The Position

The Scientist II works in the Mass Spec Bioanalysis Development group at KCAS Bio, applying bioanalytical and scientific principles to independently execute study activities with limited oversight. The role spans sample preparation, LC-MS/MS analysis, and data processing, while supporting method development, qualification, and optimization. The scientist assesses data integrity, troubleshoots technical challenges, and delivers high-quality results.

The team uses LC-MS/MS and sophisticated sample preparation methods to support drug discovery, preclinical, and clinical studies. Work includes bioanalysis of drugs and metabolites, biomarkers, and active endogenous compounds in biological fluids and tissues. The posting notes that, depending on background and qualifications, candidates may be considered for one of three Scientist levels, determined during the interview process.

Requirements

• Bachelor’s or master’s degree in chemistry, biochemistry, chemical or biochemical engineering, or a related field, with at least 2–4 years of experience with LC-MS/MS.
• Hands-on experience with bioanalytical sample preparation, quantitative LC-MS/MS, and chromatography.
• Experience supporting method development, qualification, and troubleshooting.
• Experience with small molecule analysis.
• Familiarity with reversed-phase or HILIC chromatography and standard bioanalytical workflows.

Nice To Haves

• Experience with proteins, peptides, or biomarkers.
• Experience working in a regulated environment (GLP/GxP).

Responsibilities

• Execute study activities, including sample preparation (extractions, enrichments or affinity capture, and digestions), LC-MS/MS analysis, and data processing with limited supervision.
• Support method development, qualification, and optimization activities.
• Troubleshoot technical issues and propose solutions with limited guidance.
• Analyze data and prepare summaries for senior scientists to support client updates.
• Ensure study activities comply with applicable portions of study protocols, SOPs, and regulatory requirements.
• Communicate study progress and risks to senior staff.
• Provide informal guidance to junior staff as needed.
• Perform job duties in a manner that supports the company brand, mission, vision, and values.
• Perform additional duties as requested.

Benefits

• Company-sponsored events, including food trucks, family days, and spirit days.
• Career development through KCAS University.
• Employee connections and activities related to wellness, inclusion, and community outreach.
• Stock ownership program.
• Access to the latest technology.
• Paid time off to volunteer.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level