Scientist II - LC-MS/MS Bioanalysis (Method Development)

KCAS Bio • Kansas City, KS

1d

About The Position

The Scientist II works in KCAS Bio’s Mass Spec Bioanalysis Development group, applying bioanalytical and scientific principles to independently execute study activities with limited oversight. Work includes sample preparation, LC-MS/MS analysis, and data processing, as well as support for method development, qualification, and optimization. The role requires assessing data integrity, troubleshooting technical challenges, and delivering high-quality results.

The team uses LC-MS/MS and sophisticated sample preparation methods to meet bioanalytical needs for drug discovery, preclinical, and clinical studies. Work may involve analysis of drugs and metabolites, biomarkers, and active endogenous compounds in biological fluids and tissues. The role may include providing informal guidance to junior staff and communicating study progress and risks to senior staff.

Requirements

• Bachelor’s or master’s degree in chemistry, biochemistry, chemical or biochemical engineering, or a related field.
• At least 2–4 years of experience with LC-MS/MS.
• Hands-on experience with bioanalytical sample preparation, quantitative LC-MS/MS, and chromatography.
• Experience supporting method development, qualification, and troubleshooting.
• Familiarity with reversed-phase or HILIC chromatography and standard bioanalytical workflows.

Nice To Haves

• Experience analyzing proteins, peptides, or biomarkers.
• Experience working in a regulated GLP/GxP environment.

Responsibilities

• Execute study activities, including sample preparation such as extractions, enrichments or affinity capture, and digestions; LC-MS/MS analysis; and data processing with limited supervision.
• Support method development, qualification, and optimization activities.
• Troubleshoot technical issues and propose solutions with limited guidance.
• Analyze data and prepare summaries for senior scientists to support client updates.
• Ensure study activities comply with applicable portions of study protocols, SOPs, and regulatory requirements.
• Communicate study progress and risks to senior staff.
• Provide informal guidance to junior staff as needed.
• Perform work in a manner that supports the company’s brand, mission, vision, and values.

Benefits

• Company-sponsored events, including food trucks, family days, and spirit days.
• Career development through KCAS University.
• Opportunities to connect with employees around wellness, inclusion, and community outreach.
• Stock ownership program.
• Access to the latest technology.
• Paid time off to volunteer.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level