Scientist, II

AbbVie • South San Francisco, CA

4h • $84,500 - $162,000

About The Position

AbbVie’s CAR-T Biology team in South San Francisco, part of the Immuno-Oncology Organization, is seeking a Scientist II to support the development of in vivo CAR-T platforms from concept through preclinical development. You will work at the intersection of synthetic biology and immune modulation. The ideal candidate will bring deep expertise in CAR-T biology, T-cell functional assays, and therapeutic development. The role includes designing CAR constructs, executing advanced cell-based assays and collaborating with cross-functional teams to generate high-quality data that support pipeline programs.

Requirements

• BS, or equivalent education, with typically 7 or more years of experience; or MS, or equivalent education, with typically 5 or more years of experience, in immunology, cell and molecular biology, or related field.
• Demonstrated ability to independently design, perform, and interpret key experiments to address scientific questions.
• Proven capacity to quickly learn and apply new laboratory techniques.
• Able to manage multiple tasks efficiently while meeting deadlines.
• Strong skills in scientific writing and verbal communication.
• Previous experience in chimeric antigen receptor (CAR) construct design, CAR-T production, and T cell function evaluation.
• Deep expertise in primary T cell isolation, activation, transduction, T cell cytotoxicity, proliferation, cytokine profiling, multi-color flow cytometry, and immunological assays (e.g., ELISA, Luminex, cytotoxicity assays) is required.

Nice To Haves

• Experience in cell-based in vitro assay development and semi-automated liquid handling systems for high-throughput workflows is a plus.

Responsibilities

• Design and execute in vitro assays to evaluate CAR-T biology, including assessment of cytotoxicity, T-cell effector function, and immune cell phenotyping.
• Independently establish, track, and deliver on project milestones and experimental timelines, ensuring alignment with program objectives and organizational priorities, while adapting to evolving scientific needs.
• Organize, analyze, and synthesize complex scientific data, and effectively communicate experimental strategies, results, and interpretations to internal and external stakeholders through clear and impactful presentations and scientific reports.
• Maintain comprehensive and well-documented records in an Electronic Lab Notebook (ELN).

Benefits

• paid time off (vacation, holidays, sick)
• medical/dental/vision insurance
• 401(k)
• short-term incentive programs

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level