Scientist II

Repligen Corporation•Waltham, MA

1d•Onsite

About The Position

The Scientist II, Downstream Processing will independently design, execute, and interpret studies to test and characterize new and prototype downstream processing technologies, equipment, and products for biologics and advanced therapies. This role will generate application data across areas including monoclonal antibodies, recombinant proteins, cell and gene therapies, vaccines, and related modalities, translating experimental findings into clear technical recommendations, application insights, and product performance understanding. The position requires strong scientific judgment, hands-on laboratory execution, cross-functional collaboration, and clear technical communication in support of Repligen’s R&D and product development objectives.

Requirements

Ph.D. in chemical engineering, biochemical engineering, biochemistry, biotechnology, biology, or a related scientific discipline with 2+ years of relevant experience; or M.S. with typically 5+ years; or B.S. with typically 8+ years of relevant industry experience in downstream processing, or a closely related field.
Strong technical understanding of downstream processing technologies and unit operations, including chromatography, filtration, clarification, ultrafiltration/diafiltration, sterile filtration, and related process analytical methods for biologics and advanced therapies.
Hands-on experience with basic downstream analytical assays and characterization methods such as ELISA, HPLC, SEC-MALS, SDS-PAGE, protein concentration assays, impurity assays, and related product quality or process performance analytics.
Demonstrated ability to independently design and execute experiments, interpret complex data, troubleshoot significant technical issues, and communicate recommendations clearly in reports, presentations, protocols, and cross-functional discussions.
The candidate must demonstrate critical thinking, be self-motivated, accountable, have excellent organization and communication skills, and demonstrate the ability to work independently and as a member of R&D team.
Experienced in fast paced environment with job completion deadlines.
Ability to work in a laboratory environment and follow established safety procedures, including appropriate use of personal protective equipment.
Ability to stand or sit for extended periods while performing laboratory work, data analysis, documentation, and computer-based tasks.
Ability to use standard laboratory equipment, handle small tools and instruments, and perform tasks requiring manual dexterity and attention to detail.
Ability to lift, move, or carry laboratory materials and equipment up to 25 pounds as needed.
Ability to work with chemicals, biological materials, buffers, and process samples in accordance with applicable safety and handling procedures.

Nice To Haves

Experience generating application data or evaluating new bioprocessing technologies, equipment, or consumables in an industrial biotechnology, biopharmaceutical, or life sciences environment is preferred
mammalian cell culture experience is a plus.

Responsibilities

Design, plan, and execute laboratory studies to test, characterize, and benchmark new or prototype downstream processing technologies, equipment, consumables, and products for biologics and advanced therapies, including mAbs, recombinant proteins, AAV and Lentivirus vectors, vaccines, and related modalities.
Generate application data and technical insights for downstream workflows, with strong emphasis on chromatography technologies including resins, membranes, and monoliths, as well as TFF technologies including hollow fiber and cassette-based systems.
Operate, program, and troubleshoot lab-scale chromatography systems, including AKTA systems, and lab-scale TFF systems using hollow fibers and cassettes to evaluate product performance under relevant process conditions.
Analyze experimental data, interpret technology and product performance, identify trends or limitations, and translate findings into clear technical recommendations, reports, presentations, application data packages, and customer-facing materials.
Collaborate with product development, product management and field teams to support product readiness, technical positioning, and adoption of new downstream processing technologies.
Prepare, publish, and present application data and technical findings through scientific publications, conference presentations, posters, webinars, and related external scientific communications.
Promote safe laboratory practices, data integrity, quality-driven experimentation, and effective technical communication.