Scientist, II

AbbVie•Worcester, MA

9h•$84,500 - $162,000

About The Position

AbbVie’s Gastrointestinal(GI)/Immunology Discovery Research group is looking for a highly motivated and experienced in vivo and in vitro pharmacologist to play an integral role in advancing therapeutics to treat inflammatory GI disorders. This position offers an exciting opportunity to understand the pharmacodynamic effects of experimental medicines with GI relevant in vitro and in vivo assays. The ideal candidate would work within the highly matrixed and collaborative Discovery Immunology team to guide test article screening and assay development as well as build biology packages for early stage programs. Experimental focus will be on developing and leveraging in vivo and in vitro systems to help understand the impact of test articles in mucosal immunity. The candidate is expected to design, execute, interpret and present innovative research to advance programs towards the clinic. We are seeking a hands-on experimentalist who is proficient with in vivo and in vitro cell biology research and has demonstrated scientific leadership with internal and external stake holders/experts. The expectation is that the candidate would dedicate the majority of their time toward wet lab experimentation, data analysis and presentation. In addition, we are seeking a candidate with excellent written and oral communication skills. The candidate will have the opportunity to present their results at team and internal/external science meetings. Prior technical experience in IBD mouse models, humanized mice, biologics molecule screening, and handling of human tissue are required.

Requirements

Bachelor’s Degree or equivalent education and typically, 7 years of work experience, Master’s Degree or equivalent education and typically 5 years of work experience
Highly proficient and efficient with in vivo techniques such as mouse restraint, PO, RO and IP dosing routes, and rodent necropsy.
Experience with some colitis models or humanize mouse models is required.
Technical capabilities including RT-qPCR, Western blot, multi-parameter flow cytometry
Demonstrated ability to learn, understand and master new experimental techniques.
Demonstrated scientific writing skills and strong verbal communication skills through publication and conference presentations.
Prior technical experience in IBD mouse models, humanized mice, biologics molecule screening, and handling of human tissue are required.

Nice To Haves

Experience with in vitro and in vivo cell killing endpoints preferred
Highly proficient in primary cell culture, including isolation of human and rodent cells and activation with inflammatory stimulation is preferred
Experience with ex vivo intestinal tissue assays
Possess thorough theoretical and practical understanding of own scientific discipline, especially within gastrointestinal physiology and inflammation.

Responsibilities

Highly autonomous and productive in performing laboratory research and method development, requiring only minimal direction from supervisor
Execute on discovery screening funnels for novel test articles
Design, execute and analyze in vivo pharmacology studies in colitis or other GI mouse models
Prepare and execute experiments with human blood or intestinal tissue
Formulate conclusions and design follow-on experiments based on multidisciplinary data
Primary author of regulatory documents.
Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, and animal care