Scientist II, Downstream Viral Vector Process Development

GeneFab • Alameda, CA

76d • $130,000 - $150,000

About The Position

GeneFab is seeking an experienced Downstream Process Development Scientist/Lead focused on viral vector purification (AAV and lentiviral) for in vivo gene therapy. This is a technical, project-based role in a CRDMO environment, balancing hands-on process optimization with cross-functional leadership and client-facing responsibilities.

Requirements

• Ph.D. or Master’s degree in Chemical Engineering, Biochemical Engineering, Biotechnology, or a related field.
• At least 3 years of relevant industry experience with a Ph.D., or 5 years with a Master’s degree.
• Proven expertise in downstream process development for viral vectors, particularly AAV and lentiviral vectors.
• Hands-on experience with chromatography, filtration, TFF, and other downstream processing techniques.
• Strong analytical and problem-solving skills, including the ability to interpret complex data sets.
• Excellent communication skills and ability to collaborate in a team environment.
• Knowledge of regulatory requirements and quality standards related to biopharmaceutical manufacturing.

Nice To Haves

• Experience with formulation science.

Responsibilities

• Design, optimize, and scale up downstream processes for viral vector purification, focusing on in vivo gene therapy products and lentiviral vectors.
• Execute experimental plans, analyze data, and recommend improvements to process efficiency, yield, and product quality.
• Collaborate with Upstream Process Development, Analytical Development, and Manufacturing to integrate processes.
• Troubleshoot and resolve downstream process challenges, developing robust and scalable solutions.
• Present project status updates internally and to clients.
• Stay informed about industry trends, emerging technologies, and regulatory guidelines to support process improvement and compliance.
• Provide direction and leadership to development associates as the team expands.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level