Scientist II
About The Position
HD Biosciences Inc., a WuXi AppTec company, offers biology-focused preclinical drug discovery services to biotech and pharmaceutical clients. We offer our clients comprehensive service platforms around target validation, plate-based pharmacology, hit identification and lead discovery, in vivo pharmacology, as well as other research and development services. We are seeking an initiative-taking and skilled scientist to join our fast-growing bioanalysis team. The position will independently design, execute, trouble shoot and deliver the projects with LC-MS (liquid chromatography – mass spectrometry), prioritizing large molecules such as biologics, peptides, ADCs (antibody drug conjugates), LNPs (lipid nanoparticles), and oligos, and including small molecule modalities when necessary.
Requirements
- PhD with 4+ years of relevant industry experience, MS with 7+ years of experience in Bioanalysis and Mass Spectrometry, and/or related field
- Strong scientific knowledge and hands-on technical expertise in LC-MS-based bioanalysis and drug discovery workflows.
- Industry experience in a CRO environment is highly desirable
- Demonstrated experience supporting ADC, biologic, LNP, small-molecule and/or oligonucleotide programs is strongly preferred.
- Solid understanding of qualitative and quantitative LC-MS workflows for ADCs, LNPs, peptides/proteins, biologics, small molecules, including associated sample preparation techniques
- Strong competency with a broad range of LC-MS instrumentation, including triple quadrupole (QQQ), QTOF, and Orbitrap platforms
- Hands-on experience with LC-MS method development, optimization, troubleshooting
- Experience developing and executing ADC bioanalytical assays, including characterization and/or quantification of ADCs, antibody/antibody-drug conjugate components, payloads, metabolites, and relevant catabolites
- Experience with LNP analysis by LC-MS, including characterization and/or quantitative analysis of LNP-associated components, lipid components, payloads, or related analytes
- Experience with DMPK and bioanalysis, including quantitative analysis of drug candidates and metabolites in biological matrices
- Strong experience with sample preparation from tissues, cells, plasma/serum, and other biofluids
- Proficiency with relevant data analysis and bioinformatics software, such as Skyline
- Demonstrated time management and multi-tasking skills, ability to effectively prioritize workload and manage changes in direction
- Demonstrated ability for attention to details and concern for impact
- Effective communication skills with the ability to give and receive feedback, both verbally and in writing
- Ability to work in a team environment and independently as required.
- Ability to work in a fast-paced environment
- Well organized and adaptable to changes
- Computer skills: knowledge of internet research, MS Word, Excel, Outlook, and PowerPoint. Ability to learn instrument and data analysis software
Nice To Haves
- Prior experience with in vitro assays and/or ex vivo pharmacology studies supporting drug discovery programs is a plus
- Willingness and ability to lead or support studies beyond the LC-MS area, including cross-functional projects and drug discovery activities as needed
Responsibilities
- This is a laboratory-based role. Hands-on bench work is required
- Provides scientific and operational support for bioanalysis group
- Actively contributes and applies expertise and knowledge to collaborations with partners in the design and execution of related studies
- Contributes to project proposal preparation
- Leads ongoing projects to meet expected timelines
- Contributes for new capability implementation and team building
- Contributes to the overall operations and to the achievement of departmental goals
- Communicates with clients for designing, analysis, reporting and recording activities
- Performs job specific tasks in compliance with applicable Regulations, International Standards, WuXi AppTec Policies and Standard Operating Procedures
Benefits
- An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
