Scientist II, Radiochemistry (preclinical)

Perceptive•Needham, MA

20h•Onsite

About The Position

This role offers scientific expertise in reviewing, analyzing, and resolving challenges within the radiolabeling process. Responsibilities include the design and hands-on execution of synthesis, purification, and formulation of radiotracers for use in in vivo imaging, biodistribution, and efficacy studies. The scientist will collaborate closely with cross-functional teams and manage multiple studies simultaneously to support preclinical nuclear medicine programs. Key responsibilities include working safely and compliantly with radioactive materials and operating essential lab equipment such as HPLC and Radio-TLC.

Requirements

Experience with small and large molecule radiochemistry labeling, purification, and formulation
Working knowledge and experience with HPLC and TLC techniques in radiochemistry
Ph.D. in Chemistry or relevant field with 3+ years or M.S. with 5+ years of experience in an academic or pharmaceutical lab
Experience working with radioactive materials in a safe and compliant manner
Ability to lift more than 40 pounds
Proficient with Microsoft office
English: Fluent

Nice To Haves

Experience in conjugation with chelators and labeling with radiometals is preferred.
Prior experience with F-18 radiochemistry and radioiodination methods is considered advantageous.
An effective team player with the ability to collaborate across various departments
Ability to multi-task different projects and manage time effectively
Strong written and verbal communication skills that can reach an audience of varying levels of expertise

Responsibilities

Execute and manage the production of radiotracers used in PET/SPECT imaging and therapeutic research studies.
Develop and validate: Contribute to the design, development, and optimization of radio labeled compounds targeting complex biological markers for application in PET/SPECT imaging and therapeutic studies.
Synthesis of novel PET/SPECT and SPECT and therapeutic radiopharmaceuticals
Purification methods for small and large molecules
Analytical methods for HPLC and TLC
Release criteria for imaging studies
Dose formulation processes
Operate and maintain analytical and automated radiochemistry synthesis units.
Stay current on advancements in radiochemistry and imaging through literature review and attendance at scientific conferences.
Maintain clear, accurate, and up-to-date records.
Analyze data, recognize aberrant results, and propose corrective actions or next steps
Summarize data for reports, papers, and presentations.
Manage multiple projects simultaneously and prioritize tasks effectively
Mentor and guide junior team members.
Provide scientific expertise and troubleshooting internally and in communication with Sponsors related to radiochemistry.
Perform other duties as assigned.