Scientist II Interventional Oncology

Johnson & Johnson•Spring House, PA

1d•Onsite

About The Position

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com. As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit. Job Function: Discovery & Pre-Clinical/Clinical Development Job Sub Function: Biological Research Job Category: Scientific/Technology All Job Posting Locations: Spring House, Pennsylvania, United States of America Job Description: About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine An internal pre-identified candidate for consideration has been identified. However, all applications will be considered. We are searching for the best talent for a Scientist II Interventional Oncology to join our Discovery Biology team based in Spring House, PA. The successful candidate will join a dynamic, multidisciplinary team of scientists in exploratory immuno-oncology, playing a key role in the evaluation and understanding of new drug concepts in vivo and in vitro.

Requirements

A minimum of a Bachelor’s degree in Life Sciences (e.g., Biology, Biochemistry, Pharmacology, or Tumor Immunology) with 3 to 5 years of relevant laboratory-based experience in industry, biotech, or an academic setting; alternatively, a Master’s degree (M.S.) with relevant pharmaceutical, biotech, laboratory, or academic experience
Experience with animal handling in oncology-relevant rodent models, including subcutaneous and orthotopic tumor implantation techniques, dosing, proper handling of therapeutics, tumor measurements, health monitoring, and data collection and analysis
Experience adhering to animal welfare and compliance regulations
Experience with drug administration via subcutaneous, intraperitoneal, and intravenous tail vein injections, as well as oral gavage
Experience with blood collection techniques, including tail vein, saphenous vein, and cardiac puncture
Experience performing animal autopsy/dissection, microsurgery, perfusion, and tissue collection
Familiarity with animal use protocols (AUP) and global IACUC policies

Nice To Haves

Experience with cell culture of cancer or immune cells
Experience with bioluminescent imaging, flow cytometry, immunohistochemistry (IHC), and ELISA/MSD
Strong learning agility and the ability to work across multiple projects

Responsibilities

Execute in vivo pharmacology experiments end-to-end, including tumor cell culture, tumor cell implantation, dosing, and handling of investigational drugs (including chemotherapeutics), tumor volume measurements, and collection of tissues/tumors for downstream analysis
Monitor ongoing in vivo experiments on a daily basis and collaborate closely with other scientists and SIS staff/Veterinary teams (VETs) to ensure animal welfare and health monitoring
Assist the team with the planning, design, and execution of various in vivo syngeneic and xenograft studies, utilizing established DDI guidelines for in vivo data collection, analysis, and reporting
Conduct in vitro human and ex vivo mouse immunology experiments, as required, to support the ongoing INTO portfolio or pre-portfolio programs, including assays using cancer cell, myeloid, and T-cell-based co-cultures
Demonstrate agility and learning flexibility in applying diverse cellular and molecular biology techniques, including cell/organoid assays, FACS, ELISA, MSD, and qRT-PCR
Support the Discovery Biology team with experimental setup, assay optimization, and data analysis using appropriate statistical methods, and prepare data in presentation-ready formats and for Electronic Lab Notebook (ELN) entry; provide updates in team and discovery meetings
Maintain detailed experimental records and ensure compliance with all relevant internal and external training requirements
Work as a team player and support day-to-day activities, including ordering laboratory reagents and supplies, as needed