Scientist, IHC - Histopathology

Bristol Myers Squibb • San Diego, CA

4d • Onsite

About The Position

Bristol Myers Squibb (BMS) is seeking a highly motivated and experienced pathology scientist to join the Translational Research Pathology group in San Diego, supporting the Protein Homeostasis TRC’s drug discovery and translational pathology efforts. The TRC is a fundamental Oncology research engine focused on exploiting BMS’ expertise in protein degradation to discover and develop therapies for cancer. The group collaborates with research scientists to support tissue-based target validation, animal model studies, and biomarker research from Discovery through early clinical trials. Under the leadership of an MD pathologist, the group provides pathobiology scientific expertise, diagnostic consultation, and histopathology technical support, including tissue procurement, specimen preparation, sectioning, and the development and application of novel IHC, ISH, and multiplex assays & AI/image analysis. The successful candidate will support pathobiology research by developing and applying tissue-based assays, analyzing and interpreting data, presenting results, and supporting assay transfers. They will also assist in lab operations and management of the histopathology team.

Requirements

• Bachelor’s Degree and 5+ years of academic and / or industry experience OR Master’s Degree and 3+ years of academic and / or industry experience OR Ph.D. or equivalent advanced degree in the Life Sciences with no experience necessary.
• Experience in histopathology techniques & novel IHC/IF/ISH development required.
• Good written and oral communication skills are critical, including experience in contributing to writing SOPs, reports, and presentations.
• The candidate will need to work well within a team and have strong interpersonal skills.
• Flexibility to re-focus priorities and achieve results in a frequently changing environment.

Nice To Haves

• Education and/or experience in histotechnology/pathology highly preferred.
• Experience in the biotech/diagnostic industry developing and deploying novel tissue-based assays (e.g., IHC, ISH) to support discovery/translational research by analyzing and interpreting data for project teams.
• Experience in multiplex assays and image analysis a plus.
• Should be comfortable working with pathologists in designing, interpreting, and QCing pathobiology research.
• Experience in research pathology lab operations a plus.

Responsibilities

• Lead scientist engaged in developing and verifying novel tissue-based assays (e.g., IHC, ISH), sourcing relevant sample sets, and obtaining research results to inform discovery stage to early clinical projects.
• Collaborate with research scientists & members of the pathology team (pathology scientists, image analysis scientists & pathologists) to develop experimental design & assay requirements for pathobiology research.
• Help plan and execute internal and external antibody campaigns when needed.
• Execute the development & verification of novel tissue-based assays, including multiplex IHC/IF & ISH, and some image analysis.
• Execute histopathology procedures including formalin fixed tissue trimming, tissue processing and embedding, paraffin block and frozen tissue sectioning, H&E and special stains.
• Write Standard Operating Procedures (SOPs), maintain accurate work documentation, and support assay transfers and cross-validation at CROs.
• Assist with associated operational tasks such as maintaining and updating tissue bank, slide/block storage, cell pellet, and antibody databases & share responsibilities in lab equipment scheduled maintenance and supply inventory.
• Work with lead pathologist & researchers to procure needed tissue for specific projects.
• Help manage the histopathology team by assisting with project tracking & mentoring/ training junior scientists as needed under the direction of the lab director.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree