Scientist I/II - Bioconjugation

MacroGenics, Inc.•Rockville, MD

8d•$86,100 - $146,300•Onsite

About The Position

The Scientist I/II will be an integral member of the Targeted Therapeutics Group focused on generating novel antibody-based therapies for the treatment of cancers. The successful candidate will contribute to the design, synthesis, characterization, and optimization of antibody-drug conjugates (ADCs), degrader-antibody conjugates (DACs), and other targeted therapeutic modalities. This position offers an exciting opportunity to work in a fast-paced multidisciplinary environment advancing innovative cancer therapeutics from discovery through preclinical development, and into clinical development.

Requirements

Scientist I: M.S. degree in Chemistry, Biochemistry, Chemical Biology, Pharmaceutical Sciences, or a related field with 0-2 years of direct relevant experience.
Scientist I: B.S. degree in Chemistry, Biochemistry, Chemical Biology, Pharmaceutical Sciences, or a related field with 3-5 years of direct relevant experience.
Scientist II: M.S. degree in Chemistry, Biochemistry, Chemical Biology, Pharmaceutical Sciences, or a related field with 2-5 years of direct relevant experience.
Scientist II: B.S. degree in Chemistry, Biochemistry, Chemical Biology, Pharmaceutical Sciences, or a related field with 5-8 years of direct relevant experience.
Hands-on experience in bioconjugation, protein conjugation, or antibody-drug conjugate development.
Experience with purification and characterization techniques for both small molecules and bioconjugates.
Strong understanding of protein chemistry, antibody structure, and conjugation methodologies.
Experience operating analytical instruments such as HPLC, UPLC, LC-MS, SEC, and HIC.
Excellent organizational, documentation, and communication skills.
Ability to work independently while contributing effectively within cross-functional teams.
Detail-oriented and well organized with strong written and verbal communication skills.

Nice To Haves

Experience developing ADCs, DACs, or other targeted therapeutic modalities.
Familiarity with linker-payload chemistry, site-specific conjugation, and cysteine-based conjugation strategies.
Experience with analytical analysis of conjugates: DAR, aggregation, and stability of conjugates.
Experience in synthetic organic chemistry, including the synthesis, purification, and characterization of small molecules and linker-payloads.

Responsibilities

Design and execute antibody conjugation experiments using a variety of linker-payload technologies.
Develop and optimize bioconjugation processes for ADCs, DACs, and related targeted therapeutics.
Synthesize, and optimize novel linker-payload molecules, directly contributing to next-generation ADC therapies.
Purify, characterize, and analyze synthesized molecules using analytical techniques such as HPLC, FPLC, LC-MS, and NMR.
Evaluate conjugation efficiency, drug-to-antibody ratio (DAR), aggregation, stability, and product quality attributes.
Contribute to troubleshooting, process optimization, and scale-up activities.
Collaborate closely with cross-functional teams to advance ADC programs from early discovery through preclinical and clinical development stages.
Author protocols, research reports, and intellectual property documents, while maintaining high-quality electronic laboratory records