Scientist I, Computational Chemistry

Vividion Therapeutics, Inc•San Diego, CA

14h•Onsite

About The Position

Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide foot printing of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space. We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression. Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025. We are currently seeking a Scientist I level Computational Chemist to join our fast-paced computational chemistry department. This role will be responsible for supporting drug discovery efforts across several programs at various lead optimization stages by applying structure and ligand-based CADD methods. By working closely with medicinal chemists to design new analogs for subsequent synthesis, this scientist will intellectually contribute to multiple programs to advance chemical matter across various protein targets. A successful candidate will become an essential member of the drug discovery team at Vividion. Applying their expert knowledge, they will provide insights to guide the design of new drugs and creatively implement computational methods to improve the efficacy of drug design. They will be able to balance a diverse number of projects adjusting priories based on strategic need.

Requirements

Ph.D. in computational chemistry or related field
Industrial drug discovery experience and/or post-doctoral preferred
A strong understanding of medical chemistry/SAR, structural biology, and biochemistry
Expertise in commercial molecular modeling software (Schrodinger Suite (Highly Preferred), CCG, OpenEye, etc.)
Experience with a diversity of computational methods, including but not limited to docking, MD, free energy of binding methods (highly desired), homology modeling, QSAR modeling, pharmacophore modeling, QM methods, and chemoinformatics
Experience programming or scripting (Python experience preferred)
Effective troubleshooting and problem-solving skills
Excellent computational skills
Excellent oral and written communication skills
Be an effective team player and strong individual contributor, flexible, and able to handle multiple tasks and deliver high quality results under tight timelines

Nice To Haves

Due to the nature of the work, a candidate with a strong understanding of biology is desirable.

Responsibilities

Work as an integrated member of project teams providing computational chemistry support.
Apply cutting-edge structure and ligand based CADD methods to identify and evaluate novel chemical matter with medical chemists.
Keep current in CADD methods while integrating and developing new approaches based on the project's needs.
Work with IT to maintain and expand computing resources.
Report and present work to project teams and the broader company, including education on computational methods.