Scientist, Assays and Biology - San Carlos, California

BeiGene•San Carlos, CA

3d•$136,600 - $170,700•Onsite

About The Position

At BeOne Institute, we extend BeOne’s execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles: Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles. Strategic Alignment: we prioritize disease areas that align closely with BeOne’s R&D priorities and long-term vision. Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs. As a Scientist at BeOne Institute, you will play a key role in conceptualizing, enabling, and advancing cutting-edge research at our San Carlos, CA site. As part of our team, you will design and execute experiments to identify novel targets, elucidate mechanisms, and explore new modalities and chemical matter to address unmet needs in oncology and immunology. The ideal candidate will be an innovative and curious scientist who brings creative solutions to current and emerging challenges and actively contributes to brainstorming and collaborative problem-solving. This is a rare opportunity to pursue bold ideas and help translate them into transformative medicines.

Requirements

Ph.D. or equivalent advanced degree in biology, biochemistry, chemistry, bioengineering, or a related scientific field, with relevant research experience
Strong hands-on expertise in mammalian cell biology, including experience with genetic perturbation approaches such as CRISPR-based knockout/knock-in, RNAi-mediated knockdown, or related methods
Demonstrated ability to independently design, execute, troubleshoot, and interpret experiments to investigate biological mechanisms and test scientific hypotheses
Experience generating and characterizing engineered cell lines for mechanistic studies
Experience with one or more of the following: transcriptomics (e.g., RNA-seq), chromatin profiling (e.g., ATAC-seq, CUT&RUN/CUT&Tag), high-content imaging, or other genomic and/or phenotypic profiling approaches
Strong quantitative and analytical skills, with the ability to analyze, interpret, and communicate experimental data and draw biologically meaningful conclusions
Ability to learn and apply new experimental approaches and technologies as research priorities evolve; demonstrated versatility across biological questions and experimental systems
Strong scientific judgment and problem-solving skills, with a track record of identifying experimental strategies to address challenging or ambiguous biological questions
Ability to operate effectively in a highly collaborative, fast-paced, and interdisciplinary research environment, and to integrate multi-disciplinary approaches to solve complex biological problems
Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences
Be able to work on-site in San Carlos, CA
Proficiency with electronic laboratory notebooks (ELNs) and commitment to maintaining high-quality, accurate, and reproducible experimental records

Nice To Haves

Knowledge of cancer biology, signaling pathways, and mechanisms of disease
Experience studying transcription factors and/or transcriptional regulation
Experience with chromatin biology and/or functional genomics
Experience in a drug discovery or biotechnology research environment
Experience working with challenging cell types, including primary cells or other non-standard cellular systems
Experience with in vivo research and mouse handling
Experience with induced proximity technologies or other emerging therapeutic modalities
Experience developing or adapting novel assays to address exploratory biological questions

Responsibilities

Lead or co-lead exploratory efforts on novel targets and new approaches to high impact targets within oncology, immunology, or other disease areas.
Design, enable, execute, and interpret cellular experiments to probe mechanisms and test target hypotheses.
Generate and characterize engineered cell models, including cell lines incorporating genetic perturbations such as knockouts, knockdowns, or other targeted modifications.
Develop and apply appropriate experimental approaches, including emerging technologies and profiling methods, to address complex and evolving biological questions.
Stay up-to-date on project-relevant literature and state-of-the-art techniques; be adaptable and independently follow the science.
Communicate progress through regular updates while proactively identifying challenges and proposing solutions.
Collaborate with cross-disciplinary or cross-functional teams and drive innovation within and beyond the Institute.
Contribute to management and operational activities to support strategic objectives of the BeOne Institute at the San Carlos site.
Maintain impeccable ELN records.
May be a contact for external CRO partners when needed.
May provide matrix or line-function leadership for project teams when needed.