Scientist - Antibody function and mammalian synthetic biology

Nabla Bio • Boston, MA

17h

About The Position

Nabla Bio is building AI to design new medicines. We combine cutting-edge ML with fast, human-relevant lab validation to create biomolecules on demand. This lets us go after hard diseases and build new drug formats that traditional approaches can’t reach. We’re backed by top investors like Radical and Khosla Ventures and have forged significant partnerships with leading pharma companies.

The Role
Fueled by partnerships and increasing demand for internal R&D, we will be looking to you to develop and perform high-throughput and multiplex cell-based assays for evaluating antibody function. This will include:
Engineering transient and stable cell lines with diverse reporters in both model and disease systems
Collecting and analyzing quantitative measurements using flow cytometry, immunoassays, -omics (pooled, single cell), and other techniques.
Prioritizing top development candidates by functional and binding characterization
Working together with our dry-lab and other wet-lab scientists to establish a rapid and seamless testing pipeline for characterizing machine learning generated antibody designs

Requirements

• PhD-level knowledge and experience in mammalian synthetic biology and cellular assay development
• Extensive experience in molecular biology: plasmid design, single-insert cloning, library cloning, bacterial transformation and culturing.
• Extensive experience in cell line engineering and tissue culture. Includes experience with transient and stable transfections, lentiviral transduction, electroporation; and, experience troubleshooting biological readouts.
• Well-organized, and would enjoy establishing an operationally efficient engineering and characterization pipeline that works reliably
• Problem-focused, and interested in working in a high-intensity, fast-paced environment often driven by deadlines
• Value unblocking colleagues before yourself, and are excited to mentor/train junior colleagues

Nice To Haves

• Experience culturing a wide variety of immortalized and primary disease cells is a plus.

Responsibilities

• Engineering transient and stable cell lines with diverse reporters in both model and disease systems
• Collecting and analyzing quantitative measurements using flow cytometry, immunoassays, -omics (pooled, single cell), and other techniques.
• Prioritizing top development candidates by functional and binding characterization
• Working together with our dry-lab and other wet-lab scientists to establish a rapid and seamless testing pipeline for characterizing machine learning generated antibody designs

Benefits

• A fast-moving environment where you can build and ship tools that impact real drug programs
• A small, focused team where your scientific and engineering decisions have outsized impact
• Highly competitive salary, equity, and benefits package

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 1-10 employees