Scientist 3, Functional Immunogenomics
About The Position
The Department of Cell and Tissue Genomics (CTG) at Genentech is seeking a highly motivated and innovative Scientist 3 to leverage cutting-edge genomics strategies for target discovery and next-generation therapeutic engineering. In this role, you will develop and deploy molecular engineering technologies, biologically relevant models, and state-of-the-art genomics, functional, and imaging read-outs to interrogate complex immunological disease mechanisms at scale. By integrating complex experimental systems with deep biological insights, you will directly drive the identification of novel molecular mechanisms, target candidates, and cell therapy strategies for immune-mediated diseases. The ideal candidate thrives at the interface of technology development and disease biology—building and applying cutting-edge molecular tools to extract actionable biological insights. The candidate will work collaboratively with scientists of diverse expertise, including immunology, cell therapy, genomics, human genetics, computational biology, and AI/ML. No prior industry experience required, but an open and curious scientific mind is essential, as well as strong communication skills. If you are passionate about pushing the boundaries of functional genomics to transform how we understand and treat complex immune-mediated diseases, we encourage you to apply.
Requirements
- Doctorate degree in a relevant field, including molecular biology, genetics, immunology, systems biology, synthetic biology, developmental biology, biochemistry, and/or biomedical engineering.
- Deep expertise in immunology, including primary immune cell culture and functional assays.
- Strong foundational background in molecular biology and functional genomics tools, such as CRISPR (CRISPRko, CRISPRi/a, base editing), deep mutational scanning, lineage tracing, molecular recorders.
- Experience in NGS, single-cell genomics, proteomics and/or imaging.
- Proficiency in a broad range of biochemical, molecular, and cell biology techniques including flow cytometry.
- Excellent problem-solving skills.
- Strong communication skills.
- Genuine enthusiasm for collaborative, team-based science.
- Motivation to learn new experimental approaches and computational analyses.
- Curiosity to explore unconventional ideas.
Nice To Haves
- In vivo experience a plus.
- Experience deploying molecular engineering tools at scale and in primary immune cells and/or iPSCs is a plus.
- Experience in the analysis of single cell and genomic data using R and/or Python.
Responsibilities
- Develop and deploy molecular engineering technologies, biologically relevant models, and state-of-the-art genomics, functional, and imaging read-outs to interrogate complex immunological disease mechanisms at scale.
- Integrate complex experimental systems with deep biological insights to drive the identification of novel molecular mechanisms, target candidates, and cell therapy strategies for immune-mediated diseases.
- Manage multiple projects in parallel.
- Collaborate effectively with multidisciplinary teams.
- Lead research projects.
- Design, execute, and interpret experiments.
Benefits
- Relocation benefits are available for this posting.
- A discretionary annual bonus may be available based on individual and Company performance.
- Benefits detailed at the link provided below.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
