Scientist 3 - CVRM Discovery / Research Biology

Roche • South San Francisco, CA

1d • $103,400 - $192,000 • Onsite

About The Position

The CVRM (Cardiovascular, Renal, and Metabolism) Research Biology group within Genentech Research and Early Development (gRED) is seeking a highly talented, motivated, and creative Scientist 3 to investigate novel pathways, targets, and therapeutic development in metabolic disease. The Scientist 3 contributes to the early-stage cardiometabolic pipeline across multiple therapeutic modalities and disease areas, including obesity, cardiovascular, renal, and metabolic conditions. In this lab-based role, you will work independently and collaboratively to validate new targets and pathways, leveraging in vitro, ex vivo, and in vivo skills. Reporting to a Senior Principal Scientist, you will engage in target discovery and mechanism-of-action studies while collaborating with cross-functional teams of scientists and clinicians to advance therapeutic development. This is an exciting opportunity to join a growing CVRM biology group and make significant contributions to the early stage cardiometabolic pipeline, across multiple tissues and disease areas.

Requirements

• PhD in a life science discipline (e.g., cell biology, biochemistry) or a Bachelor’s/Master’s degree with equivalent industry experience.
• Demonstrated achievement through high-quality publications and a strong understanding of cardiovascular and metabolic disease biology.
• Skilled in independent, controlled experimental design and literature review to drive mechanism-of-action studies.
• Proficient in culturing mammalian cell lines and primary cells (cardiomyocytes, immune cells, organoids, etc.).
• Experienced in cell line manipulation (e.g., CRISPR, shRNA, lentivirus) and characterization (e.g., qRT-PCR, RNAseq, Western Blot, ELISA).
• Capable of ex-vivo tissue isolation and downstream processing (e.g., protein/RNA isolation).
• Competent in plate-reader based assays, reporter assays, dose-response curve generation, and statistical analysis.
• Strong interpersonal skills with the ability to present research in cross-functional forums.

Nice To Haves

• Experience with imaging technologies (e.g., Incucyte, immunofluorescence), flow cytometry, and protein methods (e.g., IP).
• Industry experience, familiarity with cardiovascular models, and experience or willingness to develop in vivo models.

Responsibilities

• Independent design, execution and interpretation of experiments; including brainstorming of next steps and troubleshooting
• Willingness to mentor/cross-train colleagues
• Ability to present research at intra- and inter-departmental meetings
• Communicate findings through high-quality internal presentations, cross-functional forums, and external publications/conferences
• Timely adherence to ELN
• Contribute to and maintain a collaborative lab culture and safe environment

Benefits

• Relocation benefits are available for this job posting.
• A discretionary annual bonus may be available based on individual and Company performance.
• This position also qualifies for the benefits detailed at the link provided below.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree