Scientist 1, Single Cell Assay Development

10x Genomics•Pleasanton, CA

2d•Onsite

About The Position

We are seeking a motivated and driven scientist to join the Single Cell Biology group in a full-time role focused on the development and optimization of single cell assays. This role executes hands-on molecular biology work to develop, test, and refine 10x single cell workflows, and supports advanced troubleshooting for internal teams and customers. You will work in a fast-paced, multidisciplinary environment alongside colleagues in Molecular/Cell Biology, Chemistry, Fluidics, and Computational Biology. Candidates must have hands-on experience with 10x single cell assays, a strong foundation in NGS and molecular biology techniques, and the ability to apply that knowledge to troubleshoot complex systems.

Requirements

B.S./M.S. or Ph.D. in chemistry, molecular biology, biochemistry, cell biology, or a related field
B.S. with 4+ years, M.S. with 2+ years, or Ph.D. with 0–2 years of relevant biotechnology or pharmaceutical industry experience
Hands-on experience with molecular biology techniques, including nucleic acid extraction, PCR/qPCR, and NGS library preparation
Direct experience with Next-Generation Sequencing (NGS) workflows and standard molecular biology techniques
Experience with experimental design and statistical data analysis
Ability to perform complex multi-step experiments with diligent attention to planning, organization, hands-on technique, and record keeping
Strong collaboration and communication skills, with the ability to manage competing priorities
Desire to work in a flexible, fast-paced environment

Nice To Haves

Hands-on experience running 10x single cell assays
Experience working with challenging clinical sample types (e.g., FFPE tissue, primary tumor cells, low-input samples)
Familiarity with the product development lifecycle, including new product introduction and formal product testing (e.g., verification and validation)

Responsibilities

Perform standard and custom experiments to develop, test, and improve single cell assay workflows, including sample processing, library preparation, sequencing, and data analysis
Prepare high-quality NGS libraries using established molecular biology protocols
Contribute to the design, testing, and troubleshooting of new assay components and existing systems
Master the use of existing tools and defined protocols, and identify opportunities to improve them
Conceive of and develop new tools and methods to support assay development
Analyze and interpret experimental data to draw conclusions and determine next steps
Begin to collaborate cross-functionally with R&D, Support, and Marketing to advance assay development priorities
Contribute to project plans and sub-task timelines for assigned workstreams