RWE Director, Inhaled Portfolio

AstraZeneca•Wilmington, DE

7d•Hybrid

About The Position

The RWE Director, Inhaled Portfolio is a US-focused leadership role based in Wilmington, Delaware, responsible for shaping the clinical and economic value proposition for AstraZeneca’s inhaled respiratory portfolio, including Airsupra and Breztri. The role translates real-world evidence into decision-ready value stories for payers, health systems, and policy makers, with the goal of addressing evidence gaps and supporting appropriate access and use. Working across US Medical, Market Access, Field Medical, Commercial Insights, Brand, and global evidence and health economics teams, the director leads the design and delivery of evidence programs that inform strategy and practice. This includes developing integrated evidence plans and scientific narratives; designing and reporting observational studies, target trial emulations, registries, and pragmatic effectiveness research; identifying suitable real-world data; and contributing to economic models, payer dossiers, and formulary materials. The role also translates research into practical tools for field teams and works with Implementation Science counterparts to support evidence-to-practice interventions. It cultivates external research and data partnerships, promotes health equity and representative study design, applies AI/ML tools with human oversight, and ensures research meets governance, privacy, and compliance requirements. The working arrangement averages a minimum of three days per week in the office, with individual flexibility.

Requirements

Advanced degree (PhD, PharmD, MD, or relevant Master’s) in Epidemiology, Health Services Research, Health Economics, Outcomes Research, Biostatistics, or a related field.
At least 5 years of relevant RWE experience in the pharmaceutical industry, managed care, academia, or consulting.
Deep proficiency in observational study design, real-world data sources, and causal inference methods.
Comprehensive, current understanding of the US healthcare system, including payer and policy developments, quality measures, value-based care models, reimbursement dynamics, and guideline development.
Strong written and verbal communication skills, a demonstrated publication record, and the ability to translate evidence for non-technical US stakeholders.
Ability to work effectively and autonomously across US and global matrix teams.

Nice To Haves

Experience contributing to economic models, AMCP Dossiers, PVP decks, or contracting strategy inputs.
Track record of productive external partnerships with academic collaborators, registries, learning health systems, or data providers.
Familiarity with applying AI/ML tools to RWE workflows and evaluating their validity, limitations, and bias.
Respiratory experience, particularly in COPD or asthma and with inhaled or respiratory therapeutics, is strongly preferred.

Responsibilities

Partner with US Medical, Market Access, Commercial Insights, and Brand teams to define and strengthen the clinical and economic value proposition for Airsupra and Breztri, aligning evidence priorities with brand strategy and key US decision points.
Facilitate the Scientific Narrative and develop the Integrated Evidence Plan; operationalize core messages across publications, congress presentations, payer dossiers, and field resources.
Design, execute, and report observational studies, target trial emulations, registries, and pragmatic effectiveness research, using causal inference and bias-mitigation methods.
Identify, evaluate, and secure fit-for-purpose claims, EMR, registry, and linked datasets, promoting representativeness and health equity in study design.
Build and contribute to cost-effectiveness and budget impact models; author AMCP Dossier sections and provide evidence inputs for PVP decks, formulary submissions, and contracting strategy.
Translate RWE findings into actionable insights and tools for MSLs and Clinical Account Directors engaging health systems, IDNs, payers, and population health leaders.
Co-own the evidence-to-practice handoff with Implementation Science counterparts to support interventions that improve care and outcomes.
Develop collaborations with academic investigators, learning health systems, real-world data providers, patient advocacy groups, and relevant registries or quality-measure bodies.
Coordinate with global evidence and health economics counterparts to align methods and assets and ensure US outputs inform HTA submissions, economic models, and global value dossiers.
Apply AI/ML tools to literature review, automated data quality checks, and signal detection with human-in-the-loop oversight; document methods and lead peer learning.
Follow research governance processes, including protocol review and scientific committee approvals; ensure compliance with HIPAA, GCP, and internal SOPs; contribute to methods development and peer review.